Functional insulin therapy in type 1 diabetics: Short-term effects on weight and nutritional intake.

Q3 Medicine
Kamilia Ounaissa, Meriem Madhbouh, Faten Mahjoub, Nadia Ben Amor, Haifa Abdesselem, Ines Lahmar, Amel Gammoudi, Chiraz Amrouche, Henda Jamoussi Kamoun
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Abstract

Introduction-aim: Flexible insulin therapy is currently considered the gold standard therapy of type 1 diabetes. We aimed to study the evolution of glycemic control, weight and nutritional intake of a group of patients with type 1 diabetes, three months after the initiation of functional insulin therapy (FIT).

Methods: This was a prospective longitudinal study having included 30 type 1 diabetic patients hospitalized for education to FIT. Each patient underwent an assessment of glycemic control (glycated hemoglobin (A1C) and number of hypoglycemia), weight and nutritional intake before FIT and 3 months after the initiation of this educative approach.

Results: The mean age of patients was 21,8 ± 7,9 years and the sex ratio was 0,5. The mean duration of diabetes was 7,2 ± 6 years. Three months after initiation of FIT, we observed a significant lowering of A1C, which went from 9,2 ± 1,6% to 8,3 ± 1,4% (p<0,001) of the number of minor hypoglycemia (p=0,001) and that of severe hypoglycemia (p= 0,021). the average weight went from 64,6 ± 13,1 kg to 65,5 ± 13,5 kg (p = 0,040) with a significant increase in BMI (p = 0,041). Weight gain was observed in 67% of patients. This weight gain contrasted with a significant decrease in caloric (p = 0,040) and in carbohydrates intakes (p = 0,027).

Conclusion: Weight gain, associated with better glycemic control, should encourage the healthcare team to strengthen therapeutic education of patients undergoing FIT in order to limit weight gain.

1 型糖尿病患者的胰岛素功能疗法:对体重和营养摄入的短期影响。
导言-目的:灵活的胰岛素疗法目前被认为是治疗 1 型糖尿病的金标准疗法。我们旨在研究一组 1 型糖尿病患者在开始使用功能性胰岛素疗法(FIT)三个月后血糖控制、体重和营养摄入的变化情况:这是一项前瞻性纵向研究,共纳入了 30 名住院接受 FIT 教育的 1 型糖尿病患者。每位患者在接受功能性胰岛素治疗前和开始这种教育方法 3 个月后都接受了血糖控制(糖化血红蛋白 (A1C) 和低血糖次数)、体重和营养摄入的评估:患者的平均年龄为 21.8±7.9 岁,性别比为 0.5。糖尿病的平均病程为 7.2 ± 6 年。在开始使用 FIT 三个月后,我们观察到 A1C 明显降低,从 9.2 ± 1.6% 降至 8.3 ± 1.4% (p 结论:体重增加与血糖改善相关:体重增加与更好的血糖控制有关,这应鼓励医疗团队加强对接受 FIT 的患者的治疗教育,以限制体重增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Tunisie Medicale
Tunisie Medicale Medicine-Medicine (all)
CiteScore
1.00
自引率
0.00%
发文量
72
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