Experimental approaches for induction of diabetes mellitus and assessment of antidiabetic activity: An in vitro and in vivo methodological review

IF 2.1 4区医学 Q3 PHARMACOLOGY & PHARMACY

Fundamental & Clinical Pharmacology Pub Date : 2024-05-15 DOI:10.1111/fcp.13009

Shahin Gavanji, Azizollah Bakhtari, Rania Abdel-latif, Elena Bencurova, Eman M. Othman

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引用次数: 0

Abstract

Background

Diabetes mellitus poses a global health challenge, driving the need for innovative therapeutic solutions. Experimental methods play a crucial role in evaluating the efficacy of potential antidiabetic drugs, both in vitro and in vivo. Yet concerns about reproducibility persist, necessitating comprehensive reviews.

Objectives

This review aims to outline experimental approaches for inducing diabetes and evaluating antidiabetic activity, synthesizing data from authoritative sources and academic literature.

Methods

We conducted a systematic search of prominent databases, including PubMed, ScienceDirect, and Scopus, to identify relevant articles spanning from 1943 to the present. A total of 132 articles were selected for inclusion in this review, focusing on in vitro and in vivo experimental validations of antidiabetic treatments.

Results

Our review highlights the diverse array of experimental methods employed for inducing diabetes mellitus and evaluating antidiabetic interventions. From cell culture assays to animal models, researchers have employed various techniques to study the effectiveness of novel therapeutic agents.

Conclusion

This review provides a comprehensive guide to experimental approaches for assessing antidiabetic activity. By synthesizing data from a range of sources, we offer valuable insights into the current methodologies used in diabetes research. Standardizing protocols and enhancing reproducibility are critical for advancing effective antidiabetic treatments.

查看原文本刊更多论文

诱发糖尿病和评估抗糖尿病活性的实验方法：体外和体内方法综述。

背景：糖尿病对全球健康构成挑战，因此需要创新的治疗方案。实验方法在评估潜在抗糖尿病药物的体外和体内疗效方面发挥着至关重要的作用。然而，对可重复性的担忧依然存在，因此有必要进行全面综述：本综述旨在概述诱导糖尿病和评估抗糖尿病活性的实验方法，综合权威来源和学术文献中的数据：我们对包括 PubMed、ScienceDirect 和 Scopus 在内的著名数据库进行了系统检索，以确定从 1943 年至今的相关文章。本综述共选取了 132 篇文章，重点关注抗糖尿病治疗的体外和体内实验验证：结果：我们的综述强调了诱发糖尿病和评估抗糖尿病干预措施所采用的各种实验方法。从细胞培养实验到动物模型，研究人员采用了各种技术来研究新型治疗药物的有效性：本综述为评估抗糖尿病活性的实验方法提供了全面指导。通过综合各种来源的数据，我们对当前糖尿病研究中使用的方法提出了宝贵的见解。标准化方案和提高可重复性对于推进有效的抗糖尿病治疗至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fundamental & Clinical Pharmacology 医学-药学

CiteScore

5.30

自引率

6.90%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Fundamental & Clinical Pharmacology publishes reports describing important and novel developments in fundamental as well as clinical research relevant to drug therapy. Original articles, short communications and reviews are published on all aspects of experimental and clinical pharmacology including: Antimicrobial, Antiviral Agents Autonomic Pharmacology Cardiovascular Pharmacology Cellular Pharmacology Clinical Trials Endocrinopharmacology Gene Therapy Inflammation, Immunopharmacology Lipids, Atherosclerosis Liver and G-I Tract Pharmacology Metabolism, Pharmacokinetics Neuropharmacology Neuropsychopharmacology Oncopharmacology Pediatric Pharmacology Development Pharmacoeconomics Pharmacoepidemiology Pharmacogenetics, Pharmacogenomics Pharmacovigilance Pulmonary Pharmacology Receptors, Signal Transduction Renal Pharmacology Thrombosis and Hemostasis Toxicopharmacology Clinical research, including clinical studies and clinical trials, may cover disciplines such as pharmacokinetics, pharmacodynamics, pharmacovigilance, pharmacoepidemiology, pharmacogenomics and pharmacoeconomics. Basic research articles from fields such as physiology and molecular biology which contribute to an understanding of drug therapy are also welcomed.