Unraveling the Ties: Type 2 Diabetes and Parkinson's Disease - A Nano-Based Targeted Drug Delivery Approach.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM
Sourav De, Sabyasachi Banerjee, Pallabita Rakshit, Subhasis Banerjee, S K Ashok Kumar
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引用次数: 0

Abstract

The link between Type 2 Diabetes (T2DM) and Parkinson's Disease (PD) dates back to the early 1960s, and ongoing research is exploring this association. PD is linked to dysregulation of dopaminergic pathways, neuroinflammation, decreased PPAR-γ coactivator 1-α, increased phosphoprotein enriched in diabetes, and accelerated α-Syn amyloid fibril production caused by T2DM. This study aims to comprehensively evaluate the T2DM-PD association and risk factors for PD in T2DM individuals. The study reviews existing literature using reputable sources like Scopus, ScienceDirect, and PubMed, revealing a significant association between T2DM and worsened PD symptoms. Genetic profiles of T2DM-PD individuals show similarities, and potential risk factors include insulin-resistance and dysbiosis of the gut-brain microbiome. Anti-diabetic drugs exhibit neuroprotective effects in PD, and nanoscale delivery systems like exosomes, micelles, and liposomes show promise in enhancing drug efficacy by crossing the Blood-Brain Barrier (BBB). Brain targeting for PD uses exosomes, micelles, liposomes, dendrimers, solid lipid nanoparticles, nano-sized polymers, and niosomes to improve medication and gene therapy efficacy. Surface modification of nanocarriers with bioactive compounds (such as angiopep, lactoferrin, and OX26) enhances α-Syn conjugation and BBB permeability. Natural exosomes, though limited, hold potential for investigating DM-PD pathways in clinical research. The study delves into the underlying mechanisms of T2DM and PD and explores current therapeutic approaches in the field of nano-based targeted drug delivery. Emphasis is placed on resolved and ongoing issues in understanding and managing both conditions.

解开纽带:2 型糖尿病与帕金森病--一种基于纳米的靶向给药方法。
2 型糖尿病(T2DM)与帕金森病(PD)之间的联系可追溯到 20 世纪 60 年代初,目前正在对这种联系进行研究。帕金森病与多巴胺能通路失调、神经炎症、PPAR-γ辅助激活剂1-α减少、糖尿病富集的磷蛋白增加以及T2DM导致的α-Syn淀粉样纤维生成加速有关。本研究旨在全面评估 T2DM 与 PD 的关联以及 T2DM 患者 PD 的风险因素。研究利用Scopus、ScienceDirect和PubMed等权威来源对现有文献进行了回顾,发现T2DM与帕金森病症状恶化之间存在显著关联。T2DM-PD患者的遗传特征显示出相似性,潜在的风险因素包括胰岛素抵抗和肠脑微生物组失调。抗糖尿病药物对帕金森病具有神经保护作用,外泌体、胶束和脂质体等纳米级递送系统有望通过穿越血脑屏障(BBB)提高药物疗效。针对帕金森病的脑靶向治疗利用外泌体、胶束、脂质体、树枝状分子、固体脂质纳米颗粒、纳米聚合物和niosomes来提高药物和基因治疗的疗效。用生物活性化合物(如 angiopep、乳铁蛋白和 OX26)对纳米载体进行表面修饰,可增强 α-Syn 连接和 BBB 渗透性。天然外泌体虽然数量有限,但具有在临床研究中调查 DM-PD 途径的潜力。本研究深入探讨了 T2DM 和 PD 的基本机制,并探讨了纳米靶向给药领域的现有治疗方法。重点是在理解和管理这两种疾病方面已经解决和正在解决的问题。
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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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