Characterizing Vitamin B12 Deficiency in Neurology Outpatients: A Retrospective Observational Study.

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY

Clinical Neuropharmacology Pub Date : 2024-05-01 DOI:10.1097/WNF.0000000000000593

Li Zhou, Xue Bai, Bowen Wu, Yongjun Tan, Mengxia Li, Qin Yang

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引用次数: 0

Abstract

Objectives: Clinical manifestations of vitamin B12 deficiency are varied and may result in missed or delayed diagnosis. This investigation explores the diverse clinical manifestations and demographic characteristics of vitamin B12 deficiency in neurology outpatients, aiming to enhance timely diagnosis and outcomes.

Methods: The severity of vitamin B12 deficiency was classified as absolute (≤150 pg/mL) or borderline deficiency (150-300 pg/mL). We conducted a retrospective analysis of 165 outpatients with vitamin B12 deficiency at the department of neurology between May 2020 and May 2021.

Result: Absolute vitamin B12 deficiency was found in 23.0% of the patients. The most common age range was 50-60 years, the most common cause was vegetarianism, and the most common symptom was headache. Epileptiform symptoms were more likely to occur in younger patients (<20 years old) with vitamin B12 deficiency, whereas psychiatric symptoms were more likely to occur in older patients (>70 years old). Vegetarians, salivation, and nonmegaloblastic anemia were more obvious in patients with absolute vitamin B12 deficiency, whereas headaches often showed borderline B12 deficiency.

Conclusions: The clinical characteristics of vitamin B12 deficiency are complex and nonspecific. The diagnosis should be based on multiple factors.

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神经科门诊患者维生素 B12 缺乏症的特征：回顾性观察研究

目的：维生素 B12 缺乏症的临床表现多种多样，可能导致漏诊或延误诊断。本研究探讨了神经内科门诊患者维生素 B12 缺乏症的不同临床表现和人口统计学特征，旨在提高诊断的及时性和治疗效果：维生素 B12 缺乏的严重程度分为绝对缺乏（≤150 pg/mL）或边缘缺乏（150-300 pg/mL）。我们对 2020 年 5 月至 2021 年 5 月期间神经内科门诊的 165 名维生素 B12 缺乏症患者进行了回顾性分析：结果：23.0%的患者存在维生素 B12 绝对缺乏症。最常见的年龄范围为 50-60 岁，最常见的原因是素食，最常见的症状是头痛。较年轻的患者（70 岁）更容易出现癫痫样症状。素食、流涎和非巨幼红细胞性贫血在维生素 B12 绝对缺乏症患者中更为明显，而头痛则常常表现为边缘性 B12 缺乏症：维生素 B12 缺乏症的临床特征复杂且无特异性。结论：维生素 B12 缺乏症的临床特征复杂且无特异性，应根据多种因素进行诊断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuropharmacology 医学-临床神经学

CiteScore

1.20

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Neuropharmacology is a peer-reviewed journal devoted to the pharmacology of the nervous system in its broadest sense. Coverage ranges from such basic aspects as mechanisms of action, structure-activity relationships, and drug metabolism and pharmacokinetics, to practical clinical problems such as drug interactions, drug toxicity, and therapy for specific syndromes and symptoms. The journal publishes original articles and brief reports, invited and submitted reviews, and letters to the editor. A regular feature is the Patient Management Series: in-depth case presentations with clinical questions and answers.