The role of brown adipose tissue in metabolic health

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL

Chemical Research in Toxicology Pub Date : 2024-05-14 DOI:10.1038/s41574-024-00999-5

Claire Greenhill

引用次数: 0

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棕色脂肪组织在代谢健康中的作用

众所周知，棕色脂肪组织（BAT）参与产热，尤其是在啮齿类动物中。然而，棕色脂肪组织是否以及如何影响成年人的新陈代谢健康却一直不清楚。在这项研究中，研究人员培育出了BAT特异性敲除线粒体BCAA载体（MBC，由Slc25a44编码）的小鼠，这意味着线粒体BCAA分解代谢被阻断。他们还使用了同位素标记的BCAA综合追踪技术，从而能够研究细胞和小鼠体内的通量。"Kajimura说："与将BCAA作为产热燃料的观点相反，我们发现BCAA是合成多种氨基酸和谷胱甘肽的主要氮源，其中许多氨基酸和谷胱甘肽都分泌到BAT之外。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.