Sergei Kucherenko, Nannapat Sopittakamol, Nilay Shah
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引用次数: 0
Abstract
The design space (DS) is defined as the combination of materials and process conditions that guarantees the assurance of quality. This principle ensures that as long as a process operates within DS, it consistently produces a product that meets specifications. It was originally developed for a single unit system. Many industrial processes frequently involve multiple unit operations. Assessing the interaction of Critical Process Parameters (CPPs) with Critical Quality Attributes (CQAs) across stages enables informed decision-making and the capacity to balance different requirements. Analysis and visualization of the complex, multi-dimensional DS is a challenging task. This paper presents a framework for identification such DSs, considering both joint and decoupled strategies using a detailed analysis of a two-stage batch reactor case study. We assess and discuss the practicality and relevance of these methods.
期刊介绍:
Computers & Chemical Engineering is primarily a journal of record for new developments in the application of computing and systems technology to chemical engineering problems.