Innovative strategies for the surveillance, prevention, and management of pediatric infections applied to low-income settings.

IF 4.2 2区 医学 Q1 INFECTIOUS DISEASES
David Torres-Fernandez, Jessica Dalsuco, Justina Bramugy, Quique Bassat, Rosauro Varo
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引用次数: 0

Abstract

Introduction: Infectious diseases still cause a significant burden of morbidity and mortality among children in low- and middle-income countries (LMICs). There are ample opportunities for innovation in surveillance, prevention, and management, with the ultimate goal of improving survival.

Areas covered: This review discusses the current status in the use and development of innovative strategies for pediatric infectious diseases in LMICs by focusing on surveillance, diagnosis, prevention, and management. Topics covered are: Minimally Invasive Tissue Sampling as a technique to accurately ascertain the cause of death; Genetic Surveillance to trace the pathogen genomic diversity and emergence of resistance; Artificial Intelligence as a multidisciplinary tool; Portable noninvasive imaging methods; and Prognostic Biomarkers to triage and risk stratify pediatric patients.

Expert opinion: To overcome the specific hurdles in child health for LMICs, some innovative strategies appear at the forefront of research. If the development of these next-generation tools remains focused on accessibility, sustainability and capacity building, reshaping epidemiological surveillance, diagnosis, and treatment in LMICs, can become a reality and result in a significant public health impact. Their integration with existing healthcare infrastructures may revolutionize disease detection and surveillance, and improve child health and survival.

适用于低收入环境的儿科感染监测、预防和管理创新战略。
导言:传染病仍然是中低收入国家(LMICs)儿童发病和死亡的主要原因。在监测、预防和管理方面存在大量创新机会,最终目标是提高生存率:本综述通过重点关注监测、诊断、预防和管理,讨论了在低收入和中等收入国家使用和开发儿科传染病创新战略的现状。涉及的主题包括微创组织采样作为一种准确确定死因的技术;基因监测用于追踪病原体基因组多样性和抗药性的出现;人工智能作为一种多学科工具;便携式无创成像方法;预后生物标志物用于对儿科病人进行分流和风险分层:为了克服低收入和中等收入国家在儿童健康方面遇到的具体障碍,一些创新战略正处于研究的前沿。如果这些下一代工具的开发始终以可获得性、可持续性和能力建设为重点,那么重塑低收入和中等收入国家的流行病监测、诊断和治疗就能成为现实,并对公共卫生产生重大影响。这些工具与现有医疗保健基础设施的整合可能会彻底改变疾病的检测和监控,并改善儿童的健康和存活率。
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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
66
审稿时长
4-8 weeks
期刊介绍: Expert Review of Anti-Infective Therapy (ISSN 1478-7210) provides expert reviews on therapeutics and diagnostics in the treatment of infectious disease. Coverage includes antibiotics, drug resistance, drug therapy, infectious disease medicine, antibacterial, antimicrobial, antifungal and antiviral approaches, and diagnostic tests.
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