The role of bone turnover markers in diagnosis, monitoring, and pathological fractures of osteoporosis.

Kazım Ersin Altınsoy, Beytullah Unat
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引用次数: 0

Abstract

Background: We investigated the utility of specific biomarkers-namely, c-terminal telopeptide (CTX), n-telopeptide (NTX), deoxypyridinoline (DPD), and tartrate-resistant acid phosphatase (TRAP)-compared to conventional diagnostic methods. We hy-pothesized that these novel biomarkers could hold substantial value in the diagnosis, treatment, and monitoring of osteoporosis.

Methods: The study was conducted over a three-year period, from January 1, 2020, to January 1, 2023. We enrolled a total of 520 patients aged 50 years or older who had been diagnosed with osteoporosis. Patients undergoing steroid treatments, which are known to contribute to osteoporosis, were excluded from the study. Additionally, we carefully selected and matched a control group consisting of 500 patients based on demographic characteristics relevant to the diagnosis of osteoporosis. This meticulous selection process resulted in a comprehensive cohort comprising 1,020 patients. Throughout the study, patients were closely monitored for a duration of one year to track the occurrence of pathological fractures and assess their overall prognosis.

Results: As a result of our rigorous investigation, we identified CTX, NTX, DPD, and TRAP as pivotal biomarkers that play a crucial role in evaluating bone health, monitoring treatment effectiveness, and detecting pathological fractures in the context of osteoporosis.

Conclusion: Our study underscores the significance of these biomarkers in advancing the diagnosis and management of osteo-porosis, offering valuable insights into the disease's progression and treatment outcomes.

骨转换标志物在骨质疏松症的诊断、监测和病理性骨折中的作用。
背景:我们研究了特定生物标志物(即 c 端端肽(CTX)、n 端端肽(NTX)、脱氧吡啶啉(DPD)和耐酒石酸磷酸酶(TRAP))与传统诊断方法相比的效用。我们推测,这些新型生物标记物在骨质疏松症的诊断、治疗和监测方面具有重要价值:研究为期三年,从 2020 年 1 月 1 日至 2023 年 1 月 1 日。我们共招募了 520 名年龄在 50 岁或以上的骨质疏松症患者。研究排除了正在接受类固醇治疗的患者,因为众所周知类固醇会导致骨质疏松症。此外,我们还根据与骨质疏松症诊断相关的人口统计学特征,精心挑选并匹配了由 500 名患者组成的对照组。通过这一细致的筛选过程,我们建立了一个由 1,020 名患者组成的综合群组。在整个研究过程中,我们对患者进行了为期一年的密切监测,以追踪病理性骨折的发生情况并评估其总体预后:通过严格的调查,我们发现 CTX、NTX、DPD 和 TRAP 是关键的生物标志物,它们在骨质疏松症的骨健康评估、治疗效果监测和病理性骨折检测中发挥着至关重要的作用:我们的研究强调了这些生物标志物在推进骨质疏松症诊断和管理方面的重要意义,为了解疾病进展和治疗效果提供了宝贵的信息。
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