Prognostic Significance of Preoperative and Postoperative Evaluation of Combined Tumor Markers for Patients With Colon Cancer.

IF 1.1 4区医学 Q3 SURGERY

Surgical Laparoscopy, Endoscopy & Percutaneous Techniques Pub Date : 2024-08-01 DOI:10.1097/SLE.0000000000001126

Hong-Feng Pan, Zhi-Fang Zheng, Ze-Yi Zhao, Zhun Liu, Sheng-Hui Huang, Pan Chi

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引用次数: 0

Abstract

Background: The combined value of the tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in patients with colon cancer (CC) is unclear. This study aimed to investigate the role of composite tumor markers in the prognosis of CC.

Methods: Patients who underwent curative resection of colon adenocarcinoma were enrolled. The tumor marker status before and after the operation was used to divide the patients into groups according to the number of tumor markers with abnormal expression, and recurrence-free survival (RFS) and overall survival (OS) of different groups were compared. The impact of changes in composite tumor markers in the perioperative period on outcomes was further explored.

Results: Ultimately, 531 patients were enrolled in the study. As the number of preoperative and postoperative elevated tumor markers increased, both RFS and OS rates became lower (both P <0.05). Further analysis revealed that the number of elevated tumor markers after resection can significantly affect the outcomes (both P <0.05). In patients with abnormal preoperative tumor markers, normalization of markers after surgery was a protective factor for prognosis (both P <0.05), and patients with postoperative elevated levels of both tumor markers had a 5.5-fold and 6-fold increase in the risk of recurrence and death. In addition, patients with elevated markers after surgery had a high risk of recurrence within 5 years after colectomy.

Conclusions: Postoperative tumor markers had a better ability to differentiate postoperative outcomes in patients with CC than preoperative tumor markers. Patients whose tumor markers normalized after surgery had a better prognosis.

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结肠癌患者术前和术后联合肿瘤标志物评估的预后意义

背景：肿瘤标志物癌胚抗原（CEA）和碳水化合物抗原19-9（CA19-9）在结肠癌（CC）患者中的综合价值尚不明确。本研究旨在探讨复合肿瘤标志物在 CC 预后中的作用：方法：研究对象为接受结肠腺癌根治性切除术的患者。方法：以接受根治性切除术的结肠腺癌患者为研究对象，根据患者术前和术后的肿瘤标志物情况，按照肿瘤标志物异常表达的数量将患者分为不同组别，并比较不同组别的无复发生存率（RFS）和总生存率（OS）。结果：最终有 531 名患者参与了研究。随着术前和术后肿瘤标志物升高数量的增加，RFS和OS率均有所下降（均为PConclusions.OS）：与术前肿瘤标志物相比，术后肿瘤标志物更能区分CC患者的术后结果。术后肿瘤标志物恢复正常的患者预后更好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgical Laparoscopy, Endoscopy & Percutaneous Techniques 医学-外科

CiteScore

2.00

自引率

10.00%

发文量

103

审稿时长

3-8 weeks

期刊介绍： Surgical Laparoscopy Endoscopy & Percutaneous Techniques is a primary source for peer-reviewed, original articles on the newest techniques and applications in operative laparoscopy and endoscopy. Its Editorial Board includes many of the surgeons who pioneered the use of these revolutionary techniques. The journal provides complete, timely, accurate, practical coverage of laparoscopic and endoscopic techniques and procedures; current clinical and basic science research; preoperative and postoperative patient management; complications in laparoscopic and endoscopic surgery; and new developments in instrumentation and technology.