Unmet needs of biochemical biomarkers for human prion diseases.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-12-01 Epub Date: 2024-05-12 DOI:10.1080/19336896.2024.2349017

Peter Hermann, Inga Zerr

引用次数: 0

Abstract

Although the development of aggregation assays has noticeably improved the accuracy of the clinical diagnosis of prion diseases, research on biomarkers remains vital. The major challenges to overcome are non-invasive sampling and the exploration of new biomarkers that may predict the onset or reflect disease progression. This will become extremely important in the near future, when new therapeutics are clinically evaluated and eventually become available for treatment. This article aims to provide an overview of the achievements of biomarker research in human prion diseases, addresses unmet needs in the field, and points out future perspectives.

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人类朊病毒疾病对生化生物标志物的需求尚未得到满足。

尽管聚集检测方法的开发明显提高了朊病毒疾病临床诊断的准确性，但生物标志物的研究仍然至关重要。需要克服的主要挑战是非侵入性采样和探索可预测发病或反映疾病进展的新生物标志物。在不久的将来，当新的疗法经过临床评估并最终可用于治疗时，这将变得极为重要。本文旨在概述人类朊病毒疾病生物标志物研究的成就，探讨该领域尚未满足的需求，并展望未来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.