Evaluation of novel indices of walking performance taking oxygen desaturation into account during six-minute walk test in cardiovascular disease patients.

IF 1.4 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Heart and Vessels Pub Date : 2024-10-01 Epub Date: 2024-05-12 DOI:10.1007/s00380-024-02411-8
Yujiro Matsuoka, Takeshi Horio, Megumi Ono, Ryutaro Yoshimura, Kohei Fukuda, Masahiro Shimizu, Kazuhiro Nakao, Shogo Ito, Yoshiki Asakura, Yasuhiro Izumiya, Daiju Fukuda, Noriaki Kasayuki, Kohei Fujimoto
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引用次数: 0

Abstract

In pulmonary disease patients since oxygen desaturation during 6-min walk test (6MWT) affects walk distance (6MWD), some novel indices such as desaturation/distance ratio [DDR, oxygen desaturation area (DAO2)/6MWD] and distance-saturation product [DSP, 6MWD × minimum peripheral oxygen saturation (SpO2)] are evaluated. However, there has been no study examining these indices that consider exercise-induced desaturation (EID) in patients with cardiovascular disease. In 94 cardiovascular disease patients without pulmonary complications, 6MWT and echocardiography were performed at the entry of cardiac rehabilitation. SpO2 was measured during 6MWT using a continuously monitorable pulse oximeter, and DSP and DDR were calculated using minimum SpO2 and DAO2 [sum of (100-SpO2) per second during 6MWT], respectively. EID was defined as SpO2 decrease of ≥ 4% or minimum SpO2 of < 90% during 6MWT. DSP was slightly lower and DDR was markedly higher in patients with EID than in those without. When examining correlations of DSP and DDR with their components, DSP was correlated with 6MWD much closely than minimum SpO2, while DDR was correlated as closely with DAO2 as 6MWD. Furthermore, DAO2, but not minimum SpO2, had a direct correlation with 6MWD. As for associations with cardiac function, DSP was correlated with several cardiac parameters, but DDR was not correlated with any of these parameters. Our findings suggest that oxygen desaturation during 6MWT affects walking distance in cardiovascular disease patients even without pulmonary complications and that DDR is more appropriate than DSP as an index of walking performance that takes EID into consideration, independently of cardiac function.

Abstract Image

评估心血管疾病患者在六分钟步行测试中考虑氧饱和度的新型步行性能指标。
在肺部疾病患者中,由于 6 分钟步行测试(6MWT)中的氧饱和度会影响步行距离(6MWD),因此对一些新的指数进行了评估,如饱和度/距离比值[DDR,氧饱和度降低面积(DAO2)/6MWD]和距离-饱和度乘积[DSP,6MWD × 最小外周血氧饱和度(SpO2)]。然而,目前还没有研究对心血管疾病患者运动诱发的血饱和度降低(EID)进行研究。在 94 名无肺部并发症的心血管疾病患者中,在开始心脏康复治疗时进行了 6MWT 和超声心动图检查。使用可连续监测的脉搏血氧仪测量 6MWT 期间的 SpO2,并分别使用最小 SpO2 和 DAO2 [6MWT 期间每秒(100-SpO2)之和] 计算 DSP 和 DDR。EID 的定义是 SpO2 下降≥ 4% 或最小 SpO2 为 2,而 DDR 与 DAO2 的相关性与 6MWD 一样密切。此外,DAO2(而非最小 SpO2)与 6MWD 直接相关。至于与心脏功能的相关性,DSP 与几个心脏参数相关,但 DDR 与这些参数中的任何一个都不相关。我们的研究结果表明,即使没有肺部并发症,6MWT 期间的血氧饱和度也会影响心血管疾病患者的步行距离,而且 DDR 比 DSP 更适合作为考虑 EID 的步行表现指标,而与心脏功能无关。
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来源期刊
Heart and Vessels
Heart and Vessels 医学-外周血管病
CiteScore
3.10
自引率
13.30%
发文量
211
审稿时长
2 months
期刊介绍: Heart and Vessels is an English-language journal that provides a forum of original ideas, excellent methods, and fascinating techniques on cardiovascular disease fields. All papers submitted for publication are evaluated only with regard to scientific quality and relevance to the heart and vessels. Contributions from those engaged in practical medicine, as well as from those involved in basic research, are welcomed.
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