Structural dynamics in α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor gating

IF 6.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current opinion in structural biology Pub Date : 2024-05-10 DOI:10.1016/j.sbi.2024.102833

Cuauhtemoc U. Gonzalez , Vasanthi Jayaraman

引用次数: 0

Abstract

The ionotropic glutamate receptors (iGluRs) are comprised of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), N-methyl-d-aspartate receptor, kainate, and delta subtypes and are pivotal in neuronal plasticity. Recent structural studies on AMPA receptors reveal intricate conformational changes during activation and desensitization elucidating the steps from agonist binding to channel opening and desensitization. Additionally, interactions with auxiliary subunits, including transmembrane AMPA-receptor regulatory proteins, germ-cell-specific gene 1–like protein, and cornichon homologs, intricately modulate AMPA receptors. We discuss the recent high-resolution structures of these complexes that unveil stoichiometry, subunit positioning, and differences in specific side-chain interactions that influence these functional modulations.

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α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体门控的结构动力学

离子型谷氨酸受体（iGluRs）由α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）、N-甲基-d-天冬氨酸受体、凯因酸盐和 delta 亚型组成，在神经元可塑性中起着关键作用。最近对 AMPA 受体的结构研究揭示了激活和脱敏过程中复杂的构象变化，阐明了从激动剂结合到通道开放和脱敏的步骤。此外，AMPA 受体与辅助亚基（包括跨膜 AMPA 受体调节蛋白、生殖细胞特异基因 1-like 蛋白和 cornichon 同源物）之间的相互作用也对 AMPA 受体产生了复杂的调节作用。我们讨论了这些复合物的最新高分辨率结构，这些结构揭示了影响这些功能调节的配比、亚基定位和特定侧链相互作用的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in structural biology 生物-生化与分子生物学

CiteScore

12.20

自引率

2.90%

发文量

179

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Structural Biology (COSB) aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In COSB, we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. [...] The subject of Structural Biology is divided into twelve themed sections, each of which is reviewed once a year. Each issue contains two sections, and the amount of space devoted to each section is related to its importance. -Folding and Binding- Nucleic acids and their protein complexes- Macromolecular Machines- Theory and Simulation- Sequences and Topology- New constructs and expression of proteins- Membranes- Engineering and Design- Carbohydrate-protein interactions and glycosylation- Biophysical and molecular biological methods- Multi-protein assemblies in signalling- Catalysis and Regulation