Epoxy resin bioactive dental implant capped with hydroxyapatite and curcumin nanoparticles: a novel approach.

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Oral and Maxillofacial Surgery-Heidelberg Pub Date : 2024-09-01 Epub Date: 2024-05-09 DOI:10.1007/s10006-024-01252-z

Rethinam Senthil

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引用次数: 0

Abstract

Objective: In this study, the developed bioactive dental implant (BDI) from epoxy resin (ER), hydroxyapatite (HA), and curcumin nanoparticles (CUNPs).

Materials and methods: The prepared BDI were characterized using their physicochemical, mechanical, antimicrobial, bioactive, and biocompatibility study. The scanning electron microscopy (SEM) morphology of the BDI was observed HA mineralized crystal layer after being immersed in the stimulated body fluids (SBF) solution.

Results: The mechanical properties of the BDI exhibited tensile strength (250.61 ± 0.43 MPa), elongation at break (215.66 ± 0.87%), flexural modulus (03.90 ± 0.12 GPa), water absorption (05.68 ± 0.15%), and water desorption (06.42 ± 0.14%). The antimicrobial activity of BDI was observed in excellent zone of inhibition against the gram-negative (15.33 ± 0.04%) and gram- positive (15.98 ± 0.07%) bacteria. The biocompatibility study of BDI on osteoblasts cell line (MG-63) was analyzed using MTT (3-[4, 5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. The results were observed 85% viable cells present in the BDI compared to the control (only ER) samples.

Conclusions: Based on the research outcome, the BDI could be used for biomaterials application, particularly tooth dental implantation.

查看原文本刊更多论文

羟基磷灰石和姜黄素纳米颗粒包裹的环氧树脂生物活性牙科植入物：一种新方法。

研究目的本研究利用环氧树脂（ER）、羟基磷灰石（HA）和姜黄素纳米颗粒（CUNPs）开发了生物活性牙科植入物（BDI）：对制备的 BDI 进行了物理化学、机械、抗菌、生物活性和生物相容性研究。将 BDI 浸入刺激体液（SBF）溶液后，在扫描电子显微镜（SEM）下观察到 HA 矿化晶体层的形态：BDI 的机械性能表现为拉伸强度（250.61 ± 0.43 MPa）、断裂伸长率（215.66 ± 0.87%）、弯曲模量（03.90 ± 0.12 GPa）、吸水率（05.68 ± 0.15%）和脱水率（06.42 ± 0.14%）。BDI 的抗菌活性表现在对革兰氏阴性菌（15.33 ± 0.04%）和革兰氏阳性菌（15.98 ± 0.07%）有极好的抑制作用。使用 MTT（3-[4, 5-二甲基噻唑-2-基]-2,5-二苯基四唑溴化物）测定法分析了 BDI 对成骨细胞系（MG-63）的生物相容性。结果显示，与对照组（仅ER）相比，BDI 样品中有 85% 的细胞存活：根据研究结果，BDI 可用于生物材料应用，尤其是牙齿种植。

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来源期刊

Oral and Maxillofacial Surgery-Heidelberg DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.20

自引率

5.60%

发文量

118

期刊介绍： Oral & Maxillofacial Surgery founded as Mund-, Kiefer- und Gesichtschirurgie is a peer-reviewed online journal. It is designed for clinicians as well as researchers.The quarterly journal offers comprehensive coverage of new techniques, important developments and innovative ideas in oral and maxillofacial surgery and interdisciplinary aspects of cranial, facial and oral diseases and their management. The journal publishes papers of the highest scientific merit and widest possible scope on work in oral and maxillofacial surgery as well as supporting specialties. Practice-oriented articles help improve the methods used in oral and maxillofacial surgery.Every aspect of oral and maxillofacial surgery is fully covered through a range of invited review articles, clinical and research articles, technical notes, abstracts, and case reports. Specific topics are: aesthetic facial surgery, clinical pathology, computer-assisted surgery, congenital and craniofacial deformities, dentoalveolar surgery, head and neck oncology, implant dentistry, oral medicine, orthognathic surgery, reconstructive surgery, skull base surgery, TMJ and trauma.Time-limited reviewing and electronic processing allow to publish articles as fast as possible. Accepted articles are rapidly accessible online.Clinical studies submitted for publication have to include a declaration that they have been approved by an ethical committee according to the World Medical Association Declaration of Helsinki 1964 (last amendment during the 52nd World Medical Association General Assembly, Edinburgh, Scotland, October 2000). Experimental animal studies have to be carried out according to the principles of laboratory animal care (NIH publication No 86-23, revised 1985).