Switching CGRP(r) MoAbs in migraine: what evidence?

IF 3.6 3区医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Expert Opinion on Biological Therapy Pub Date : 2024-05-01 Epub Date: 2024-05-14 DOI:10.1080/14712598.2024.2354386

William David Wells-Gatnik, Paolo Martelletti

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引用次数: 0

Abstract

Introduction: Approximately 50% of patients that receive a CGRP(r) MoAb for the preventative treatment of migraine are expected to discontinue therapy. For patients that discontinue CGRP(r) MoAb therapy, few clinical options are available. One potential option is to switch CGRP(r) MoAbs, however, data concerning the efficacy of this intervention is scarce.

Areas covered: This manuscript aims to summarize all available data concerning the potential efficacy of switching CGRP(r) MoAbs following previous medication discontinuation. Data was sourced by completing a database search for the terms: 'CGRP monoclonal antibody switch OR CGRP monoclonal antibody switching.'

Expert opinion: While data considering the potential efficacy of CGRP(r) switching continues to grow, our expert opinion supports the most recent European Headache Federation statement regarding CGRP(r) MoAb prescribing practices, concluding that there remains insufficient data to determine the efficacy of this intervention. As this topic is of significant clinical importance, we recommend a call-to-action to expand on current data considering the therapeutic options for patients that discontinue CGRP(r) MoAb therapy.

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偏头痛中的 CGRP(r) MoAbs 转换：证据何在？

简介：在接受CGRP(r) MoAb预防性治疗偏头痛的患者中，预计约有50%的患者会中断治疗。对于中断 CGRP(r) MoAb 治疗的患者，可供选择的临床方案很少。一种可能的选择是更换 CGRP(r) MoAbs，但有关这种干预措施疗效的数据很少：本手稿旨在总结有关在停药后更换 CGRP(r) MoAbs 潜在疗效的所有可用数据。数据来源于数据库搜索，搜索关键词为专家意见：尽管考虑 CGRP(r) 转换潜在疗效的数据不断增加，但我们的专家意见支持欧洲头痛联盟关于 CGRP(r) MoAb 处方实践的最新声明，其结论是目前仍没有足够的数据来确定这种干预措施的疗效。由于该主题具有重要的临床意义，我们建议采取行动，扩展现有数据，考虑中止 CGRP(r) MoAb 治疗的患者的治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Opinion on Biological Therapy 医学-生物工程与应用微生物

CiteScore

8.60

自引率

0.00%

发文量

审稿时长

3-8 weeks

期刊介绍： Expert Opinion on Biological Therapy (1471-2598; 1744-7682) is a MEDLINE-indexed, international journal publishing peer-reviewed research across all aspects of biological therapy. Each article is structured to incorporate the author’s own expert opinion on the impact of the topic on research and clinical practice and the scope for future development. The audience consists of scientists and managers in the healthcare and biopharmaceutical industries and others closely involved in the development and application of biological therapies for the treatment of human disease. The journal welcomes: Reviews covering therapeutic antibodies and vaccines, peptides and proteins, gene therapies and gene transfer technologies, cell-based therapies and regenerative medicine Drug evaluations reviewing the clinical data on a particular biological agent Original research papers reporting the results of clinical investigations on biological agents and biotherapeutic-based studies with a strong link to clinical practice Comprehensive coverage in each review is complemented by the unique Expert Collection format and includes the following sections: Expert Opinion – a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results; Article Highlights – an executive summary of the author’s most critical points.