Impact of diabetes on the prognosis of patients with oral and oropharyngeal cancer: A meta-analysis

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation Pub Date : 2024-05-10 DOI:10.1111/jdi.14223

Wei Xu, Zhi Chen, Laijian Zhang

{"title":"Impact of diabetes on the prognosis of patients with oral and oropharyngeal cancer: A meta-analysis","authors":"Wei Xu, Zhi Chen, Laijian Zhang","doi":"10.1111/jdi.14223","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Aims/Introduction</h3>\n \n <p>Diabetes has been related to an increased risk of oral cancer. Nevertheless, the impact of diabetes on the outcome of individuals with oral and oropharyngeal cancer is not clear. In this study, a meta-analysis was carried out to assess the link between diabetes and the survival of individuals with oral and oropharyngeal cancer.</p>\n </section>\n \n <section>\n \n <h3> Materials and Methods</h3>\n \n <p>Relevant cohort studies for the meta-analysis objective were obtained through searching electronic databases, such as PubMed, Web of Science and Embase. The data were combined using a random effects model that accounted for differences between studies.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>A total of 10 cohorts involving 21,871 patients with oral and oropharyngeal cancer were included. Pooled results suggest that compared with those with normoglycemia, oral and oropharyngeal cancer patients with diabetes were associated with a poor overall survival (hazard ratio 1.69, 95% confidence interval 1.29–2.22, <i>P</i> < 0.001; <i>I</i><sup>2</sup> = 69%). Subgroup analysis suggested a stronger association between diabetes and poor overall survival in patients aged ≥52 years as compared with those aged <52 years (hazard ratio 2.08 vs 1.34, <i>P</i> = 0.03). Other study characteristics, such as study country, tumor stage or follow-up duration, did not seem to significantly affect the association (<i>P</i> for subgroup difference all >0.05). In addition, diabetes was also associated with a poor progression-free survival of patients with oral and oropharyngeal cancer (hazard ratio 1.61, 95% confidence interval 1.30–1.99, <i>P</i> < 0.001; <i>I</i><sup>2</sup> = 9%).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Patients with oral and oropharyngeal cancer might have a poor survival if they have pre-existing diabetes.</p>\n </section>\n </div>","PeriodicalId":51250,"journal":{"name":"Journal of Diabetes Investigation","volume":"15 8","pages":"1140-1150"},"PeriodicalIF":3.1000,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11292398/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Diabetes Investigation","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jdi.14223","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Aims/Introduction

Diabetes has been related to an increased risk of oral cancer. Nevertheless, the impact of diabetes on the outcome of individuals with oral and oropharyngeal cancer is not clear. In this study, a meta-analysis was carried out to assess the link between diabetes and the survival of individuals with oral and oropharyngeal cancer.

Materials and Methods

Relevant cohort studies for the meta-analysis objective were obtained through searching electronic databases, such as PubMed, Web of Science and Embase. The data were combined using a random effects model that accounted for differences between studies.

Results

A total of 10 cohorts involving 21,871 patients with oral and oropharyngeal cancer were included. Pooled results suggest that compared with those with normoglycemia, oral and oropharyngeal cancer patients with diabetes were associated with a poor overall survival (hazard ratio 1.69, 95% confidence interval 1.29–2.22, P < 0.001; I² = 69%). Subgroup analysis suggested a stronger association between diabetes and poor overall survival in patients aged ≥52 years as compared with those aged <52 years (hazard ratio 2.08 vs 1.34, P = 0.03). Other study characteristics, such as study country, tumor stage or follow-up duration, did not seem to significantly affect the association (P for subgroup difference all >0.05). In addition, diabetes was also associated with a poor progression-free survival of patients with oral and oropharyngeal cancer (hazard ratio 1.61, 95% confidence interval 1.30–1.99, P < 0.001; I² = 9%).

Conclusions

Patients with oral and oropharyngeal cancer might have a poor survival if they have pre-existing diabetes.

Abstract Image

查看原文本刊更多论文

糖尿病对口腔癌和口咽癌患者预后的影响：荟萃分析

目的/引言：糖尿病与口腔癌风险增加有关。然而，糖尿病对口腔癌和口咽癌患者预后的影响尚不明确。本研究进行了一项荟萃分析，以评估糖尿病与口腔癌和口咽癌患者生存之间的联系：通过搜索 PubMed、Web of Science 和 Embase 等电子数据库，获得了与荟萃分析目标相关的队列研究。采用随机效应模型对数据进行合并，以考虑不同研究之间的差异：结果：共纳入了 10 项队列研究，涉及 21,871 名口腔癌和口咽癌患者。汇总结果表明，与血糖正常的患者相比，口腔癌和口咽癌患者的总生存率较低（危险比 1.69，95% 置信区间 1.29-2.22，P 2 = 69%）。亚组分析表明，与年龄在 0.05 岁的患者相比，年龄≥52 岁的患者患糖尿病与总生存率低之间的关系更为密切。）此外，糖尿病还与口腔癌和口咽癌患者无进展生存期差有关（危险比 1.61，95% 置信区间 1.30-1.99，P 2 = 9%）：结论：口腔癌和口咽癌患者如果患有糖尿病，其生存率可能较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).