Brielle Stawicki, Tyler Schacher, Anna Dushenkov, Paiboon Jungsuwadee
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引用次数: 0
Abstract
The promising results seen in the treatment of refractory hematologic malignancies with tisagenlecleucel (Kymriah), the pioneering Chimeric Antigen Receptor (CAR) T-cell immunotherapy, has stimulated a fast growth in research and clinical testing of novel CAR-T constructs, targets, and various generations of CAR T-cells. Pharmacists may receive inquiries about active clinical trials or may be contributing to the care of patients participating in these studies. This briefing discusses the on-going clinical trials that explore novel CAR T-cell immunotherapies in pediatric refractory malignancies of hematologic and solid organ origins. It can be valuable in assisting practitioners in navigating the rapidly evolving field of CAR T-cell immunotherapies.
Tisagenlecleucel (Kymriah)是嵌合抗原受体（CAR）T 细胞免疫疗法的先驱，它在治疗难治性血液恶性肿瘤方面取得了令人鼓舞的成果，这刺激了新型 CAR-T 构建、靶点和各代 CAR T 细胞研究和临床试验的快速发展。药剂师可能会收到有关正在进行的临床试验的咨询，也可能要为参与这些研究的患者提供护理。本简报讨论了正在进行的临床试验，这些试验探讨了新型 CAR T 细胞免疫疗法在小儿难治性血液和实体器官恶性肿瘤中的应用。它可以帮助从业人员了解快速发展的 CAR T 细胞免疫疗法领域。
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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