Neurodevelopmental Follow-Up of Children Born to Mothers with Graves' Disease and Neonatal Hyperthyroidism.

IF 2.6 3区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Francisca Grob, Amy Brown, Margaret Zacharin
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引用次数: 0

Abstract

Introduction: Neonatal hyperthyroidism, often caused by maternal Graves' disease (GD), carries potential neurodevelopmental risks for children. Excessive thyroid hormones during fetal development are linked to neurological issues like ADHD and epilepsy. However, the impact of transient neonatal hyperthyroidism is not well understood.

Methods: In a retrospective study at the Royal Children's Hospital in Melbourne, 21 neonates with hyperthyroidism from mothers with GD were examined. Of these, the parents of 10 children consented to participate; thus, questionnaires assessing executive functions, behavior, and social communication were completed. The outcomes were compared to those of control subjects recruited from the community using standardized tools (BRIEF, SDQ, SCQ). The results were analyzed against socio-demographic factors, maternal, and neonatal health.

Results: No significant demographic or clinical differences were found between study participants (n = 10) and non-participants (n = 11). Participants, compared to controls, showed similar family demographics but a higher proportion of control parents had university-level education (p = 0.003). Patients displayed more social (SCQ scores: 12.1 ± 2.5 vs. 6 ± 1.07, p = 0.008) and behavioral difficulties (SDQ scores: 10.2 ± 2.17 vs. 6.14 ± 1.03, p = 0.03), with increased executive function challenges (BRIEF scores indicating problem-solving and self-regulation difficulties). Significant effects of family living situation and partner education level on neurodevelopmental measures were noted, underscoring the influence of socio-demographic factors.

Conclusions: These findings suggest neonatal hyperthyroidism might lead to subtle neurodevelopmental variations, with socio-economic elements and family dynamics possibly intensifying these effects. While most children did not show severe impairments, early detection and intervention are recommended. The research emphasizes the necessity for inclusive care approaches that consider socio-economic factors for children affected by neonatal hyperthyroidism.

随访患有巴塞杜氏病和新生儿甲状腺功能亢进症的母亲所生子女的神经发育情况。
导言:新生儿甲状腺功能亢进症通常由母体巴塞杜氏病(GD)引起,对儿童的神经发育具有潜在风险。胎儿发育过程中过量的甲状腺激素与多动症和癫痫等神经系统问题有关。然而,人们对一过性新生儿甲状腺功能亢进症的影响还不甚了解:在墨尔本皇家儿童医院进行的一项回顾性研究中,研究人员对21名患有甲状腺功能亢进症的新生儿进行了检查。其中,10 名患儿的父母同意参与研究;因此,他们填写了评估执行功能、行为和社会交流的问卷。研究结果与使用标准化工具(BRIEF、SDQ、SCQ)从社区招募的对照对象的结果进行了比较。结果与社会人口因素、产妇和新生儿健康状况进行了对比分析:研究参与者(10 人)与非参与者(11 人)在人口统计学和临床方面没有发现明显差异。与对照组相比,参与者的家庭人口统计学特征相似,但对照组父母中受过大学教育的比例更高(P=0.003)。患者表现出更多的社交障碍(SCQ 得分:12.1±2.5 vs. 6±1.07,p=0.008)和行为障碍(SDQ 得分:10.2±2.17 vs. 6.14±1.03,p=0.03),执行功能方面的挑战增加(BRIEF 得分显示解决问题和自我调节方面的困难)。家庭生活状况和伴侣受教育程度对神经发育测量有显著影响,凸显了社会人口因素的影响:这些研究结果表明,新生儿甲状腺功能亢进症可能会导致神经发育的微妙变化,而社会经济因素和家庭动态可能会加剧这些影响。虽然大多数患儿没有表现出严重的障碍,但仍建议及早发现并进行干预。这项研究强调,对于受新生儿甲状腺功能亢进症影响的儿童,有必要采取考虑到社会经济因素的包容性护理方法。
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来源期刊
Hormone Research in Paediatrics
Hormone Research in Paediatrics ENDOCRINOLOGY & METABOLISM-PEDIATRICS
CiteScore
4.90
自引率
6.20%
发文量
88
审稿时长
4-8 weeks
期刊介绍: The mission of ''Hormone Research in Paediatrics'' is to improve the care of children with endocrine disorders by promoting basic and clinical knowledge. The journal facilitates the dissemination of information through original papers, mini reviews, clinical guidelines and papers on novel insights from clinical practice. Periodic editorials from outstanding paediatric endocrinologists address the main published novelties by critically reviewing the major strengths and weaknesses of the studies.
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