Electroanalytical Properties of Unmodified and Modified Solid-Contact Potentiometric β-Lactam Sensors in Aqueous and Biological Media

IF 0.9 4区材料科学 Q4 MATERIALS SCIENCE, MULTIDISCIPLINARY

Inorganic Materials Pub Date : 2024-03-20 DOI:10.1134/S002016852314008X

E. G. Kulapina, R. K. Mursalov, O. I. Kulapina, V. D. Ankina

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Abstract

A comparative study of the electroanalytical properties of solid-contact sensors (tubular, planar) in solutions of cefuroxime (Cefur), cefotaxime (Ceftx), cefixime (Cefix), and amoxicillin (Amox) is performed. Associates of tetraalkylammonium—tetradecylammonium (TDA) and dimethyldistearylammonium (DMDSA)—with complex compounds of silver(I) and β-lactam antibiotics [Ag(β-lac)₂]TAA and modifiers such as ZnO, polyaniline, and polyaniline nanotubes are used as electrode-active components (EACs). The sensors under study based on [Ag(Cefur)₂]TDA and [Ag(Amox)₂]DMDSA are characterized by a short response time in solutions of cefotaxime, cefuroxime, cefixime, and amoxicillin: 20–25 and 12–17 s for tubular unmodified and modified, respectively; 20–25 and 10–15 s for planar unmodified and modified, respectively. The linear range of electrode functions in solutions of antibiotics is 1 × 10^–4–1 × 10^–2 mol/L; the limit of detection is 2.5 × 10^–5–8.9 × 10^–5 mol/L for unmodified, 5.6 × 10^–6–7.5 × 10^–5 mol/L for modified, and 4.2 × 10^–5–7.2 × 10^–5 mol/L for planar sensors. The potential drift is 8–12 mV/day for unmodified and 5–7 mV/day for modified planar sensors; the service life is 1.5–2 months. An advantage of planar sensors is their use in microassay detection, which is relevant in the analysis of biological media. Application of solid-contact sensors for determination of the antibiotics under study in model aqueous solutions, medicinal products, and oral fluid in the case of various infectious diseases is demonstrated.

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水介质和生物介质中未改性和改性固体接触式电位计 β-内酰胺传感器的电分析特性

摘要对固体接触传感器（管状、平面）在头孢呋辛（Cefur）、头孢他啶（Ceftx）、头孢克肟（Cefix）和阿莫西林（Amox）溶液中的电分析特性进行了比较研究。四烷基铵--十四烷基铵（TDA）和二甲基双十八烷基铵（DMDSA）--与银（I）和β-内酰胺类抗生素[Ag(β-lac)2]TAA的复合物以及改性剂（如氧化锌、聚苯胺和聚苯胺纳米管）的结合体被用作电极活性成分（EAC）。所研究的基于[Ag(Cefur)2]TDA 和[Ag(Amox)2]DMDSA 的传感器在头孢他啶、头孢呋辛、头孢克肟和阿莫西林溶液中的响应时间很短：管状未修饰和修饰的响应时间分别为 20-25 秒和 12-17 秒；平面未修饰和修饰的响应时间分别为 20-25 秒和 10-15 秒。在抗生素溶液中，电极功能的线性范围为 1 × 10-4-1 × 10-2 mol/L；非改性传感器的检测限为 2.5 × 10-5-8.9 × 10-5 mol/L，改性传感器的检测限为 5.6 × 10-6-7.5 × 10-5 mol/L，平面传感器的检测限为 4.2 × 10-5-7.2 × 10-5 mol/L。未改良平面传感器的电位漂移为 8-12 mV/天，改良平面传感器的电位漂移为 5-7 mV/天；使用寿命为 1.5-2 个月。平面传感器的一个优点是可用于微量检测，这与生物介质分析有关。我们展示了固体接触式传感器在各种传染病的模型水溶液、医药产品和口服液中用于测定抗生素的应用。

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来源期刊

Inorganic Materials 工程技术-材料科学：综合

CiteScore

1.40

自引率

25.00%

发文量

审稿时长

3-6 weeks

期刊介绍： Inorganic Materials is a journal that publishes reviews and original articles devoted to chemistry, physics, and applications of various inorganic materials including high-purity substances and materials. The journal discusses phase equilibria, including P–T–X diagrams, and the fundamentals of inorganic materials science, which determines preparatory conditions for compounds of various compositions with specified deviations from stoichiometry. Inorganic Materials is a multidisciplinary journal covering all classes of inorganic materials. The journal welcomes manuscripts from all countries in the English or Russian language.