Numerical Studies on Magnetic Driven Targeted Drug Delivery in Human Vasculature

IF 1.8 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of the Indian Institute of Science Pub Date : 2024-05-05 DOI:10.1007/s41745-024-00428-6

Nikhil Kumar Tamboli, Janani Srree Murallidharan

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Abstract

Magnetic driven targeted drug delivery (TDD) involves the manipulation of magnetic drug carriers, such as nano/micro particles or bubbles, within the body using external magnetic fields to precisely reach the intended target location. This method is utilized in treating severe illnesses like cancerous tumors and nervous disorders, offering higher efficacy with reduced drug dosages and side effects. While numerous studies have simulated magnetic driven TDD, comprehensive reviews remain scarce. This article presents an extensive review of computational/numerical work done on magnetic driven TDD utilizing both microbubbles and non-bubbles (nano/micro particles) within human vasculature and lung airways. The study aims to analyze the drug delivery problem from physical and numerical perspectives. Key highlights include artery wall models (rigid, flexible, or porous), models of force acting on particles, relevant governing equations, discussions on parameters of interest and their effects on drug delivery efficacy. Finally, the article briefly outlines common trends observed in magnetic driven TDD problems and their underlying physical principles.

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人体血管中磁驱动靶向给药的数值研究

磁驱动靶向给药（TDD）是指利用外部磁场在体内操纵磁性药物载体（如纳米/微粒或气泡），使其精确到达预定的靶点。这种方法可用于治疗癌症肿瘤和神经紊乱等严重疾病，在减少药物剂量和副作用的同时提高疗效。虽然有许多研究对磁驱动 TDD 进行了模拟，但全面的综述仍然很少。本文广泛综述了利用微气泡和非气泡（纳米/微粒）在人体血管和肺部气道中进行磁驱动 TDD 的计算/数值工作。研究旨在从物理和数值角度分析药物输送问题。重点内容包括动脉壁模型（刚性、柔性或多孔性）、作用于颗粒的力模型、相关控制方程、相关参数及其对给药效果影响的讨论。最后，文章简要概述了在磁驱动 TDD 问题中观察到的常见趋势及其基本物理原理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Indian Institute of Science MULTIDISCIPLINARY SCIENCES-

CiteScore

4.30

自引率

0.00%

发文量

期刊介绍： Started in 1914 as the second scientific journal to be published from India, the Journal of the Indian Institute of Science became a multidisciplinary reviews journal covering all disciplines of science, engineering and technology in 2007. Since then each issue is devoted to a specific topic of contemporary research interest and guest-edited by eminent researchers. Authors selected by the Guest Editor(s) and/or the Editorial Board are invited to submit their review articles; each issue is expected to serve as a state-of-the-art review of a topic from multiple viewpoints.