Sentinel lymph node detection with indocyanine green and patent blue dye in cervical cancer: A single-centre feasibility study.

IF 1.4 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Australian & New Zealand Journal of Obstetrics & Gynaecology Pub Date : 2024-05-07 DOI:10.1111/ajo.13834

Marta Preston, Rosemary McBain, Niveditha Rajadevan, Antonia Jones, Deborah Neesham, Orla McNally

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引用次数: 0

Abstract

Background: Sentinel lymph node (SLN) dissection has been established as standard of care in many tumours. Its use in early cervical cancer is an area of increasing interest and some studies suggest a high detection rate.

Aim: To explore feasibility of SLN dissection and establish the patient detection rate in women with early cervical cancer.

Materials and methods: All patients with early cervical cancer, International Federation of Gynaecology and Obstetrics (FIGO) 2018 Stage 1, of any histology who underwent SLN dissection from January 2017 to March 2023 were included. Patients were eligible if they had pelvic confined disease; no suspicious lymph nodes on pre-operative imaging or intra-operatively; tumours <4 cm at the time of surgery and no contra-indications to surgery. Patients were excluded if there was a known allergy to dye or less than six months follow-up data.

Results: Sixty-two patients were included in the study and 53% had FIGO stage 1b1 disease. The overall bilateral SLN detection rate was 89%, and the side-specific rate was 94%. Where indocyanine green (ICG) was used alone, the bilateral detection rate was 87% and the side-specific rate was 93%. Where ICG was used with patent blue dye (PTB) the bilateral detection rate was 92% and the side-specific rate was 96%. Where PTB was used alone the bilateral detection rate was 85% and the side-specific rate was 92%. The node positive rate was 6% (7/124) which included isolated tumour cells in four patients.

Conclusion: SLN dissection with ICG or PTB is feasible in early-stage cervical cancer.

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使用吲哚菁绿和漆蓝染料进行宫颈癌前哨淋巴结检测：单中心可行性研究。

背景：前哨淋巴结（SLN）清扫术已被确定为许多肿瘤的标准治疗方法。目的：探讨前哨淋巴结清扫术的可行性，并确定早期宫颈癌女性患者的检出率：纳入2017年1月至2023年3月期间接受SLN切除术的所有早期宫颈癌患者，国际妇产科联盟（FIGO）2018年1期，任何组织学。如果患者患有盆腔局限性疾病；术前成像或术中无可疑淋巴结；肿瘤结果：研究共纳入62名患者，53%的患者为FIGO 1b1期疾病。双侧 SLN 总检出率为 89%，一侧检出率为 94%。单独使用吲哚菁绿（ICG）时，双侧检出率为 87%，一侧检出率为 93%。当 ICG 与专利蓝染料（PTB）一起使用时，双侧检出率为 92%，两侧特异性检出率为 96%。单独使用 PTB 时，双侧检出率为 85%，一侧检出率为 92%。结节阳性率为 6%（7/124），其中包括 4 名患者的孤立肿瘤细胞：结论：使用 ICG 或 PTB 对早期宫颈癌进行 SLN 切除是可行的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Australian & New Zealand Journal of Obstetrics & Gynaecology 医学-妇产科学

CiteScore

3.40

自引率

11.80%

发文量

165

审稿时长

4-8 weeks

期刊介绍： The Australian and New Zealand Journal of Obstetrics and Gynaecology (ANZJOG) is an editorially independent publication owned by the Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG) and the RANZCOG Research foundation. ANZJOG aims to provide a medium for the publication of original contributions to clinical practice and/or research in all fields of obstetrics and gynaecology and related disciplines. Articles are peer reviewed by clinicians or researchers expert in the field of the submitted work. From time to time the journal will also publish printed abstracts from the RANZCOG Annual Scientific Meeting and meetings of relevant special interest groups, where the accepted abstracts have undergone the journals peer review acceptance process.