Investigation of Novel Urinary Biomarkers in Hepatocellular Carcinoma Risk in a Predominantly African American Population: A Case-Control Study.

IF 0.8 Q4 GASTROENTEROLOGY & HEPATOLOGY
Gastrointestinal Tumors Pub Date : 2024-03-08 eCollection Date: 2023-01-01 DOI:10.1159/000538131
Alexandra Shingina, Xijing Han, Lei Fan, Harvey Murff, Robert Coffey, Ginger L Milne, Qi Dai, Martha Shrubsole
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引用次数: 0

Abstract

Introduction: African Americans are at increased risk of hepatocellular carcinoma (HCC) compared to other racial and ethnic groups. We investigated the associations of four urinary biomarkers of prostaglandin E2 (PGE-M), prostacyclin (PGI-M), and thromboxane (11dTxB2) synthesis and the ratio of PGI-M to 11dTXB2 with HCC risk in a cohort of predominantly African American populations.

Methods: We conducted a nested case-control study (50 cases; 43 with HCC, 151 controls) in the Southern Community Cohort Study (SCCS), a large prospective cohort study including over 80,000 study participants, of whom two-thirds are African Americans. Urine samples were collected at enrollment and subsequently analyzed to assess biomarker levels. Multivariable regression models adjusted for age, race, sex, BMI, smoking status, NSAID use, education level, income, and alcohol consumption were used to assess the relationship between the biomarker and HCC risk.

Results: Only 11dTxB2 (OR = 11.50; 95% CI [2.34-56.47] for highest tertile vs. lowest tertile, p = 0.004) and the PGI-M/11dTXB2 ratio of the second quartile (0.25-0.49) (OR = 5.16; 95% CI [1.44-18.47]; p = 0.01) were significantly associated with increased risk of liver cancer.

Conclusion: 11dTXB2 and PGI-M/11dTXB2 ratio may be urinary markers of HCC risk, particularly among African Americans, and future prospective studies are needed to evaluate this finding further and to develop accessible methods.

调查以非洲裔美国人为主的人群中肝细胞癌风险的新型尿液生物标志物:病例对照研究
导言:与其他种族和族裔群体相比,非裔美国人患肝细胞癌(HCC)的风险更高。我们研究了以非裔美国人为主的队列中前列腺素 E2 (PGE-M)、前列环素 (PGI-M) 和血栓素 (11dTxB2) 合成的四种尿液生物标志物以及 PGI-M 与 11dTXB2 的比率与 HCC 风险的关系:我们在南方社区队列研究(SCCS)中进行了一项巢式病例对照研究(50 例病例;43 例 HCC 患者,151 例对照),这是一项大型前瞻性队列研究,包括 80,000 多名研究参与者,其中三分之二是非裔美国人。研究人员在入组时收集了尿液样本,随后对其进行了分析,以评估生物标志物水平。使用调整了年龄、种族、性别、体重指数、吸烟状况、非甾体抗炎药使用情况、教育水平、收入和饮酒量的多变量回归模型来评估生物标志物与 HCC 风险之间的关系:结果:只有11dTxB2(OR = 11.50; 95% CI [2.34-56.47] for highest tertile vs. lowest tertile, p = 0.004)和第二四分位数(0.25-0.49)的PGI-M/11dTXB2比值(OR = 5.16; 95% CI [1.44-18.47]; p = 0.01)与肝癌风险增加显著相关。结论:11dTXB2和PGI-M/11dTXB2比值可能是HCC风险的尿液标记物,尤其是在非裔美国人中,未来需要进行前瞻性研究来进一步评估这一发现并开发可获得的方法。
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来源期刊
Gastrointestinal Tumors
Gastrointestinal Tumors GASTROENTEROLOGY & HEPATOLOGY-
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审稿时长
17 weeks
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