The impact of baseline dietary fatty acid intake on the association between lipoprotein(a) and mortality in two US cohorts.

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

JRSM Cardiovascular Disease Pub Date : 2024-04-11 eCollection Date: 2024-01-01 DOI:10.1177/20480040241247394

Nimai Patel, Chaitanya Chennareddy, Eric J Brandt

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引用次数: 0

Abstract

Background: Lipoprotein(a) (Lp(a)) is an established casual risk factor for atherosclerotic cardiovascular disease. It remains unknown whether dietary fat modifies the association of Lp(a) with cardiovascular death.

Aim: To understand if dietary fat modifies the association between Lp(a) and cardiovascular death.

Methods: We utilized the Atherosclerotic Risk in Communities (ARIC) study and National Health and Nutrition Examination Survey (NHANES) III cohorts and used multivariate cox proportional hazard modeling to test the association between Lp(a), dietary fats, and cardiovascular death.

Results: The sample (n = 22,805) had average age 51.3 years and was mostly female (55.4%). Lp(a) ≥ 30 mg/dL was associated with CV death in both ARIC (1.36, p = 0.001) and NHANES (1.31, p = 0.03). In multivariate analysis, no categorical or individual fatty acids modified the association between Lp(a) and CV death.

Conclusion: There was no evidence that baseline dietary fat intake modified the association between Lp(a) and CV death.

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美国两个队列中基线膳食脂肪酸摄入量对脂蛋白（a）与死亡率之间关系的影响。

背景：脂蛋白（a）（Lp(a)）是动脉粥样硬化性心血管疾病的一个公认的偶然危险因素。目的：了解膳食脂肪是否会改变脂蛋白（a）与心血管死亡之间的关系：方法：我们利用社区动脉粥样硬化风险（ARIC）研究和美国国家健康与营养调查（NHANES）III队列，使用多变量cox比例危险模型检验脂蛋白（a）、膳食脂肪和心血管死亡之间的关联：样本（n = 22 805）的平均年龄为 51.3 岁，大部分为女性（55.4%）。在 ARIC（1.36，p = 0.001）和 NHANES（1.31，p = 0.03）中，脂蛋白（a）≥ 30 mg/dL 与心血管死亡相关。在多变量分析中，没有任何分类或单个脂肪酸能改变脂蛋白（a）与冠心病死亡之间的关系：结论：没有证据表明基线膳食脂肪摄入量会改变脂蛋白（a）与冠心病死亡之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JRSM Cardiovascular Disease CARDIAC & CARDIOVASCULAR SYSTEMS-

自引率

6.20%

发文量

审稿时长

12 weeks