Individual and institutional predisposing factors of MRSA surgical site infection and outcomes-a retrospective case-control-study in 14 European high-volume surgical centres.

IF 3.7 Q2 INFECTIOUS DISEASES
JAC-Antimicrobial Resistance Pub Date : 2024-04-04 eCollection Date: 2024-04-01 DOI:10.1093/jacamr/dlae046
Jule Rutz, Jan-Hendrik Naendrup, Caroline Bruns, Annika Y Classen, Jon Salmanton-García, Harald Seifert, Rosanne Sprute, Jannik Stemler, Sarah V Walker, Oliver A Cornely, Blasius J Liss, Sibylle C Mellinghoff
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引用次数: 0

Abstract

Objectives: To assess incidence rates of surgical site infections (SSI) by MRSA and to determine related factors and clinical outcome compared to MSSA, including country-specific, institutional and patient determinants.

Patients and methods: We performed a subgroup analysis of the Europe-wide SALT (NCT03353532) study population with MRSA SSI from 14 centres in France, Germany, Italy, Spain and the UK.

Results: An overall MRSA SSI incidence of 0.06% (n = 104) was found in 178 903 patients undergoing invasive surgery in 2016. Frequently observed comorbidities were chronic cardiovascular disease, diabetes and solid tumours. Compared to the overall MRSA SSI incidence, incidence rates were significantly higher in Spain (58 of 67 934 cases) and lower in Germany (16 of 46 443 cases; both P < 0.05). Centres with antibiotic stewardship (ABS) and infectious disease (ID) consultation programmes (n = 3/14) had lower MRSA rates (17 of 43 556 cases versus 61 of 83 048 cases, P < 0.05). In bivariate analyses, MRSA SSI patients were significantly older, had higher BMI and more comorbidities compared to MSSA (P < 0.05 each). Surgery performed between 6:00 and 12:00 pm led to higher MRSA proportions among S. aureus SSI (17 of 104 cases versus 62 of 640 cases, P < 0.05).

Conclusions: This study shows low overall and country-specific incidence rates of MRSA SSI in Europe. We could show significant differences between countries as well as between centres with established ABS and ID consultation programmes were observed. The number of those programmes seems too small against this background.

欧洲 14 家大手术中心 MRSA 手术部位感染的个人和机构诱发因素及结果--一项回顾性病例对照研究。
目的:评估 MRSA 手术部位感染(SSI)的发生率,并确定与 MSSA 相比的相关因素和临床结果:评估MRSA引起的手术部位感染(SSI)的发病率,并确定与MSSA相比的相关因素和临床结果,包括特定国家、机构和患者的决定因素:我们对来自法国、德国、意大利、西班牙和英国的14个中心的全欧洲SALT(NCT03353532)研究人群中的MRSA SSI患者进行了分组分析:在2016年接受侵入性手术的178 903名患者中,MRSA SSI总发病率为0.06%(n = 104)。常见合并症为慢性心血管疾病、糖尿病和实体瘤。与 MRSA SSI 的总体发病率相比,西班牙的发病率明显较高(67 934 例中的 58 例),德国的发病率较低(46 443 例中的 16 例;均为 P n = 3/14),MRSA 的发病率较低(43 556 例中的 17 例与 83 048 例中的 61 例相比,P P 金黄色葡萄球菌 SSI(104 例中的 17 例与 640 例中的 62 例相比,P 结论:这项研究表明,欧洲 MRSA SSI 的总体发病率和特定国家的发病率都很低。我们可以发现,不同国家之间以及拥有既定 ABS 和 ID 咨询计划的中心之间存在明显差异。在此背景下,这些计划的数量似乎太少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.30
自引率
0.00%
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审稿时长
16 weeks
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