Peritumoral stroma and systemic inflammatory response in cervical cancer.

IF 0.5 Q4 OBSTETRICS & GYNECOLOGY

Ceska Gynekologie-Czech Gynaecology Pub Date : 2024-01-01 DOI:10.48095/cccg202495

Sérgio Santana Otano, Anelise Mendes Melo, Fernanda Beatriz Ferreira Souza, Jéssica Souto Morlin, Eliângela de Castro Côbo, Ana Cristina Macêdo Barcelos, Adilha Misson Rua Micheletti, Millena Prata Jammal, Eddie Fernando Candido Murta, Rosekeila Simões Nomelini

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引用次数: 0

Abstract

Objective: To compare cervical stroma in advanced cervical cancer with the control group; to compare, in the pre-treatment period, hemogram parameters in patients with advanced cervical cancer with the same parameters as the control group; and to verify if there is an association of stromal markers with prognostic factors in cervical cancer.

Materials and methods: We prospectively evaluated 16 patients diagnosed with advanced invasive cervical cancer. A control group of 22 patients was used (uterine leiomyoma). Immunohistochemistry was performed to verify the stromal immunostaining of alpha-smooth muscle actin (SMA) and fibroblast activation protein alpha (FAP). Immunostainings and hemogram parameters were compared using Fisher's exact and Mann-Whitney Test, respectively.

Results: Strong FAP immunostaining was more frequent in patients with cervical cancer when compared with patients with leiomyoma (P = 0.0002). Regarding SMA, strong immunostaining was also found more in the group of cancer patients compared to the control group (P < 0.00001). The neutrophil-lymphocyte ratio (NLR) values were higher in the cancer patient group compared to the control group (P = 0.0019). There was no association of the parameters studied with prognostic factors.

Conclusions: Strong FAP and SMA immunostaining was found more in patients with cervical cancer when compared to the control group. NLR values were also higher in cervical cancer.

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宫颈癌的瘤周基质和全身炎症反应

目的比较晚期宫颈癌患者的宫颈基质与对照组；比较晚期宫颈癌患者治疗前的血象参数与对照组的相同参数；验证基质标记物与宫颈癌预后因素是否存在关联：我们对16名确诊为晚期浸润性宫颈癌的患者进行了前瞻性评估。对照组有 22 名患者（子宫肌瘤）。采用免疫组化方法验证了α-平滑肌肌动蛋白（SMA）和成纤维细胞活化蛋白α（FAP）的基质免疫染色。免疫染色和血象参数分别采用费雪精确检验和曼惠尼检验进行比较：结果：与子宫肌瘤患者相比，宫颈癌患者更常出现强 FAP 免疫染色（P = 0.0002）。在 SMA 方面，与对照组相比，癌症患者组中也发现了更多的强免疫染色（P < 0.00001）。与对照组相比，癌症患者组的中性粒细胞-淋巴细胞比值（NLR）更高（P = 0.0019）。研究参数与预后因素没有关联：结论：与对照组相比，宫颈癌患者的 FAP 和 SMA 免疫染色更强。宫颈癌患者的 NLR 值也更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ceska Gynekologie-Czech Gynaecology OBSTETRICS & GYNECOLOGY-

CiteScore

0.60

自引率

25.00%

发文量