Comparison of HIF-1α and survivin levels in patients with diabetes and retinopathy of varying severity.

IF 1.1 4区医学 Q3 OPHTHALMOLOGY

Arquivos brasileiros de oftalmologia Pub Date : 2024-04-19 eCollection Date: 2024-01-01 DOI:10.5935/0004-2749.2023-0112

Burak Bilgin, Semsettin Bilak, Yusuf Özay

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Abstract

Purpose: This study measured serum hypoxia--inducible factor-1 (HIF-1α) and survivin levels in patients with diabetes and investigated their association with the severity of retinopathy.

Methods: This study included 88 patients with type 2 diabetes mellitus who underwent routine eye examinations. Three groups were created. Group 1 consisted of patients without diabetic retinopathy. Group 2 included patients with non-proliferative diabetic retinopathy. Group 3 included patients with proliferative diabetic retinopathy. To measure serum HIF-1α and survivin levels, venous blood samples were collected from patients.

Results: The mean HIF-1α levels in groups 1, 2, and 3 were 17.30 ± 2.19, 17.79 ± 2.34, and 14.19 ± 2.94 pg/ml, respectively. Significant differences were detected between groups 1 and 3 (p=0.01) and between groups 2 and 3 (p=0.01). The mean survivin levels in groups 1, 2, and 3 were 42.65 ± 5.37, 54.92 ± 5.55, and 37.46 ± 8.09 pg/ml, respectively. A significant difference was only detected between groups 2 and 3 (p=0.002).

Conclusion: The present study revealed that serum HIF-1α and survivin levels are increased in patients with non-proliferative diabetic retinopathy compared to those in patients without diabetic retinopathy.

查看原文本刊更多论文

糖尿病和不同严重程度视网膜病变患者体内 HIF-1α 和存活素水平的比较。

目的：本研究测定了糖尿病患者血清中缺氧诱导因子-1（HIF-1α）和存活素的水平，并探讨了它们与视网膜病变严重程度的关系：本研究纳入了88名接受常规眼科检查的2型糖尿病患者。研究分为三组。第一组为无糖尿病视网膜病变的患者。第二组包括非增殖性糖尿病视网膜病变患者。第三组包括增殖性糖尿病视网膜病变患者。为了测量血清中HIF-1α和survivin的水平，采集了患者的静脉血样本：结果：第 1、2 和 3 组的平均 HIF-1α 水平分别为 17.30 ± 2.19、17.79 ± 2.34 和 14.19 ± 2.94 pg/ml。第 1 组和第 3 组之间（P=0.01）以及第 2 组和第 3 组之间（P=0.01）存在显著差异。第 1、2 和 3 组的平均存活素水平分别为 42.65 ± 5.37、54.92 ± 5.55 和 37.46 ± 8.09 pg/ml。只有第 2 组和第 3 组之间存在明显差异（P=0.002）：本研究显示，与无糖尿病视网膜病变的患者相比，非增殖性糖尿病视网膜病变患者血清中的 HIF-1α 和存活素水平升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arquivos brasileiros de oftalmologia OPHTHALMOLOGY-

CiteScore

1.60

自引率

0.00%

发文量

200

审稿时长

6-12 weeks

期刊介绍： The ABO-ARQUIVOS BRASILEIROS DE OFTALMOLOGIA (ABO, ISSN 0004-2749 - print and ISSN 1678-2925 - (ABO, ISSN 0004-2749 - print and ISSN 1678-2925 - electronic version), the official bimonthly publication of the Brazilian Council of Ophthalmology (CBO), aims to disseminate scientific studies in Ophthalmology, Visual Science and Health public, by promoting research, improvement and updating of professionals related to the field.