[Experts' consensus on mammalian cardiomyocyte regeneration].

Q3 Medicine
生理学报 Pub Date : 2024-04-25
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引用次数: 0

Abstract

Myocardial infarction (MI) leads to a massive loss of cardiomyocytes, resulting in pathological cardiac remodeling and heart failure. Promoting cardiomyocyte regeneration is crucial for repairing the damaged heart. It is acknowledged that regenerative cardiomyocyte derives from the existing cardiomyocytes. In recent years, advancements in this field have updated our understanding of cardiomyocyte regeneration in many aspects, including intrinsic cell source and microenvironmental characteristics, extrinsic factors, molecular biology mechanisms, and intervention strategies. Here, we report a consensus by an expert committee on the definition, characteristics, evaluation, research methods, regulatory mechanisms, and intervention measures related to mammalian cardiomyocyte regeneration. The aim is to clarify important unresolved issues in this field and to promote myocardial regeneration research and its clinical translation.

[哺乳动物心肌细胞再生专家共识]。
心肌梗死(MI)会导致心肌细胞大量丢失,造成病理性心脏重塑和心力衰竭。促进心肌细胞再生是修复受损心脏的关键。众所周知,再生心肌细胞来源于现有的心肌细胞。近年来,该领域的研究进展更新了我们对心肌细胞再生的认识,包括内在细胞来源和微环境特征、外在因素、分子生物学机制和干预策略等多个方面。在此,我们报告专家委员会就哺乳动物心肌细胞再生的定义、特征、评估、研究方法、调控机制和干预措施达成的共识。目的是澄清该领域尚未解决的重要问题,促进心肌再生研究及其临床转化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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