[Advances in the study of the actin nucleation factor Spire].

Q3 Medicine
生理学报 Pub Date : 2024-04-25
Tao Pang, Li-Xia Zhang, An-Na Bai, Wen Yang, Li-Xia Hao
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引用次数: 0

Abstract

There are three main classes of actin nucleation factors: Arp2/3 complexes, Spire and Formin. Spire assembles microfilaments by nucleating stable longitudinal tetramers and binding actin to the growing end of the microfilament. As early as 1999, Wellington et al. identified Spire as an actin nucleating agent, however, over the years, most studies have focused on Arp2/3 and Formin proteins; there has been relatively less research on Spire as a member of the actin nucleating factors. Recent studies have shown that Spire is involved in the vesicular transport through the synthesis of actin and plays an important role in neural development. In this paper, we reviewed the structure, expression and function of Spire, and its association with disease in order to identify meaningful potential directions for studies on Spire.

[肌动蛋白成核因子 Spire 的研究进展]。
肌动蛋白成核因子主要有三类:Arp2/3 复合物、Spire 和 Formin。Spire 通过核化稳定的纵向四聚体并将肌动蛋白结合到微丝的生长端来组装微丝。早在 1999 年,Wellington 等人就发现 Spire 是一种肌动蛋白成核因子,但多年来,大多数研究都集中在 Arp2/3 和 Formin 蛋白上,对 Spire 作为肌动蛋白成核因子成员的研究相对较少。最近的研究表明,Spire 通过合成肌动蛋白参与囊泡运输,并在神经发育中发挥重要作用。本文综述了 Spire 的结构、表达和功能及其与疾病的关系,以确定有意义的 Spire 潜在研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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