Preparation and Physicochemical Properties of a Thermosensitive Hydrogel-based Lipopeptide Biosurfactant

IF 1.2 4区医学 Q4 CHEMISTRY, MEDICINAL

Letters in Drug Design & Discovery Pub Date : 2024-04-30 DOI:10.2174/0115701808296878240419065845

Sepehr Afsharipour, Mohammad Amin Raeisi Estabragh, Amirhossein Namaki, Mandana Ohadi, Mohammad Hassan Moshafi, Ibrahim M. Banat, Gholamreza Dehghannoudeh

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Abstract

Background: Temperature-sensitive (thermo-sensitive) formulations are a novel drug delivery dosage form that shows bio-inspired behavior in various applications. The structure and properties of a thermosensitive polymer are critical in designing an intelligent biometric polymer that contains lipopeptide biosurfactants. Objectives: In this study, thermo-sensitive hydrogels with lipopeptide biosurfactants as a potential wound dressing dosage form were formulated and examined regarding physicochemical properties. Methods: The lipopeptide biosurfactants were isolated from the Acinetobacter junni B6 bacterial strain and loaded on a formulation of poloxamer 407® and carboxymethyl cellulose as a gelling agent. Numerous experiments were carried out to evaluate the physicochemical properties of these formulations, such as the stability, spreadability, release profile, and kinetic. Results: The formulation (Poloxamer 407® (19% w/v), carboxymethyl cellulose (2% w/v), lipopeptide biosurfactants (5mg/mL), benzyl alcohol (1% v/v), and 0.1mL polyethylene glycol 400) was select as the optimum formulation. The selected formulation released 26.9% of the lipopeptide biosurfactants with anomalous transport kinetics after 10 hours. Conclusions: The results showed that a thermo-sensitive formulation could help achieve a sustained release of lipopeptide biosurfactants and potentially be used as a dressing formulation for wounds in future studies.

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热敏性水凝胶脂肽生物表面活性剂的制备与理化特性

背景：温度敏感（热敏）制剂是一种新型的给药剂型，在各种应用中都表现出生物启发行为。热敏聚合物的结构和特性对于设计含有脂肽生物表面活性剂的智能生物计量聚合物至关重要。研究目的本研究配制了含有脂肽生物表面活性剂的热敏水凝胶，并对其理化性质进行了研究。研究方法从云氏不动杆菌 B6 菌株中分离出脂肽生物表面活性剂，并将其添加到以 poloxamer 407® 和羧甲基纤维素为胶凝剂的配方中。为评估这些制剂的理化特性，如稳定性、铺展性、释放曲线和动力学特性，进行了大量实验。实验结果Poloxamer 407® (19% w/v)、羧甲基纤维素 (2% w/v)、脂肽生物表面活性剂 (5mg/mL)、苯甲醇 (1% v/v) 和 0.1mL 聚乙二醇 400）被选为最佳配方。10 小时后，所选配方释放了 26.9% 的脂肽生物表面活性剂，且运输动力学异常。结论研究结果表明，热敏配方有助于实现脂肽生物表面活性剂的持续释放，并有可能在未来的研究中用作伤口敷料配方。

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来源期刊

Letters in Drug Design & Discovery 医学-医药化学

CiteScore

1.80

自引率

10.00%

发文量

245

审稿时长

3 months

期刊介绍： Aims & Scope Letters in Drug Design & Discovery publishes letters, mini-reviews, highlights and guest edited thematic issues in all areas of rational drug design and discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. The emphasis is on publishing quality papers very rapidly by taking full advantage of latest Internet technology for both submission and review of manuscripts. The online journal is an essential reading to all pharmaceutical scientists involved in research in drug design and discovery.