Wei Xu, Huiting Li, Ziyao Wang, Yan Kang, Luojie Zheng, Yiping Liu, Ping Xu, Zheng Li
{"title":"LINC00152: Potential driver oncogene in pan-cancer","authors":"Wei Xu, Huiting Li, Ziyao Wang, Yan Kang, Luojie Zheng, Yiping Liu, Ping Xu, Zheng Li","doi":"10.1002/wrna.1851","DOIUrl":null,"url":null,"abstract":"Long noncoding RNAs (lncRNA) are a class of non-coding RNAs greater than 200 bp in length with limited peptide-coding function. The transcription of <i>LINC00152</i> is derived from chromosome 2p11.2. Many studies prove that <i>LINC00152</i> influences the progression of various tumors via promoting the tumor cells malignant phenotype, chemoresistance, and immune escape. <i>LINC00152</i> is regulated by multiple transcription factors and DNA hypomethylation. In addition, <i>LINC00152</i> participates in the regulation of complex molecular signaling networks through epigenetic regulation, protein interactions, and competitive endogenous RNA (ceRNA). Here, we provide a systematic review of the upstream regulatory factors of <i>LINC00152</i> expression level in different types of tumors. In addition, we revisit the main functions and mechanisms of <i>LINC00152</i> as driver oncogene and biomarker in pan-cancer.","PeriodicalId":519538,"journal":{"name":"WIREs RNA","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"WIREs RNA","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/wrna.1851","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Long noncoding RNAs (lncRNA) are a class of non-coding RNAs greater than 200 bp in length with limited peptide-coding function. The transcription of LINC00152 is derived from chromosome 2p11.2. Many studies prove that LINC00152 influences the progression of various tumors via promoting the tumor cells malignant phenotype, chemoresistance, and immune escape. LINC00152 is regulated by multiple transcription factors and DNA hypomethylation. In addition, LINC00152 participates in the regulation of complex molecular signaling networks through epigenetic regulation, protein interactions, and competitive endogenous RNA (ceRNA). Here, we provide a systematic review of the upstream regulatory factors of LINC00152 expression level in different types of tumors. In addition, we revisit the main functions and mechanisms of LINC00152 as driver oncogene and biomarker in pan-cancer.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
