The Shape Trail Test Is Sensitive in Differentiating Older Adults with Mild Cognitive Impairment: A Culture-neutral Five-minute Test

IF 4.3 Q2 BUSINESS
Z. Ding, Agnes S. Chan
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Abstract

Introduction

The Shape Trail Test (STT) was developed based upon the Trail Making Test, as a culture-neutral test for measuring processing speed and mental flexibility. This study aims to evaluate the accuracy and validity of this five-minute test for differentiating individuals with normal cognition (NC), subjective memory impairment (SMI), and mild cognitive impairment (MCI).

Method

The study included 210 participants aged 50–80 years, with 70 participants in each group matched for age, education, and gender.

Results

No significant difference in STT measures was found between the NC and SMI groups. In contrast, both the NC and SMI groups exhibited significantly better performance (shorter completion time in STT-A and STT-B and fewer STT-B errors) than the MCI group. No significant group differences were found in STT-A errors. Stepwise regression analysis identified three significant predictors for classifying the MCI group from the NC and/or SMI groups, including the STT-B completion time, the STT-A errors, and the interaction between STT-B completion time and STT-B errors. The composite score of these three predictors demonstrated good discriminatory power for classifying the MCI group from the other groups, with area under the curves (AUCs) of 0.76–0.79 (p < 0.001), sensitivities of 78.6%–80%, and specificities of 60%–61.4%. However, none of the STT measures or their interactions were significant predictors for differentiating the SMI group from the NC group. Besides, the STT measures were significantly correlated with age, education, and executive function measures.

Discussion

The STT could be a culture- and language-free, reliable test for assessing executive function and a sensitive test for predicting MCI.

Abstract Image

形状轨迹测试在区分患有轻度认知障碍的老年人方面很敏感:文化中立的五分钟测试
导言形状轨迹测验(STT)是在轨迹制作测验的基础上开发出来的,它是一种文化中立的测验,用于测量处理速度和思维灵活性。本研究旨在评估这一五分钟测试在区分认知正常(NC)、主观记忆障碍(SMI)和轻度认知障碍(MCI)个体方面的准确性和有效性。相反,NC 组和 SMI 组的表现(STT-A 和 STT-B 完成时间较短,STT-B 错误较少)明显优于 MCI 组。在 STT-A 错误方面没有发现明显的组间差异。逐步回归分析确定了将 MCI 组与 NC 和/或 SMI 组进行分类的三个重要预测因子,包括 STT-B 完成时间、STT-A 错误以及 STT-B 完成时间与 STT-B 错误之间的交互作用。这三个预测因子的综合得分在将 MCI 组与其他组进行分类方面表现出良好的区分能力,曲线下面积(AUC)为 0.76-0.79(p < 0.001),灵敏度为 78.6%-80%,特异度为 60%-61.4%。然而,STT 测量或其交互作用都不是区分 SMI 组和 NC 组的显著预测指标。讨论 STT是一种不受文化和语言影响的可靠的执行功能测试,也是预测MCI的灵敏测试。
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来源期刊
The Journal of Prevention of Alzheimer's Disease
The Journal of Prevention of Alzheimer's Disease Medicine-Psychiatry and Mental Health
CiteScore
9.20
自引率
0.00%
发文量
0
期刊介绍: The JPAD Journal of Prevention of Alzheimer’Disease will publish reviews, original research articles and short reports to improve our knowledge in the field of Alzheimer prevention including: neurosciences, biomarkers, imaging, epidemiology, public health, physical cognitive exercise, nutrition, risk and protective factors, drug development, trials design, and heath economic outcomes.JPAD will publish also the meeting abstracts from Clinical Trial on Alzheimer Disease (CTAD) and will be distributed both in paper and online version worldwide.We hope that JPAD with your contribution will play a role in the development of Alzheimer prevention.
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