On the Hunt for the Missed Genetic Causes of Multiple Primary Tumors

IF 2.9 3区医学 Q2 ONCOLOGY

Cancer Prevention Research Pub Date : 2024-05-02 DOI:10.1158/1940-6207.capr-24-0115

Fiona Chan-Pak-Choon, William D. Foulkes

引用次数: 0

Abstract

Improved cancer screening and treatment programs have led to an increased survivorship of patients with cancer, but consequently also to the rise in number of individuals with multiple primary tumors (MPT). Germline testing is the first approach investigating the cause of MPT, as a positive result provides a diagnosis and proper clinical management to the affected individual and their family. Negative or inconclusive genetic results could suggest non-genetic causes, but are negative genetic results truly negative? Herein, we discuss the potential sources of missed genetic causes and highlight the trove of knowledge MPT can provide. See related article by Borja et al., p. 209

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寻找多发性原发性肿瘤被遗漏的遗传原因

癌症筛查和治疗计划的改进提高了癌症患者的存活率，但同时也导致了多发性原发性肿瘤（MPT）患者人数的增加。种系检测是调查多发性原发性肿瘤病因的首要方法，因为阳性结果可为患者及其家人提供诊断和适当的临床治疗。阴性或不确定的基因检测结果可能提示非遗传原因，但阴性基因检测结果真的是阴性的吗？在此，我们将讨论遗漏遗传病因的潜在来源，并强调 MPT 可以提供的知识宝库。参见 Borja 等人的相关文章，第 209 页

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Prevention Research 医学-肿瘤学

CiteScore

6.00

自引率

3.00%

发文量

173

审稿时长

1 months

期刊介绍： Cancer Prevention Research publishes original studies, reviews, and perspectives in the field of cancer prevention. Its scope includes the molecular and cellular biology of premalignancy and early lesions; genetic and environmental risk factors; risk assessment and reduction; early detection research (cancer screening and diagnosis); and preventive interventions (chemoprevention, immunoprevention, and others) to intercept cancer development at early stages prior to initiation, promotion, or progression. The journal comprises preclinical, clinical, and translational research, with special attention given to molecular discoveries and an emphasis on building a translational bridge between the basic and clinical sciences.