Curcumin attenuates brain aging by reducing apoptosis and oxidative stress

IF 3.2 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Metabolic brain disease Pub Date : 2024-04-30 DOI:10.1007/s11011-023-01326-z

Mehran Cheriki, Masoumeh Habibian, Seyyed Jafar Moosavi

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Abstract

Brain aging is a physiological event, and oxidative stress and apoptosis are involved in the natural aging process of the brain. Curcumin is a natural antioxidant with potent anti-aging and neuroprotective properties. Therefore, we investigated the protective effects of curcumin on brain apoptosis and oxidative stress, brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) in aged rats. Old female Wistar rats were randomly divided into three groups (n = 7); as follows: (1) control; (2); saline and (3) curcumin (received 30 mg/kg of curcumin, 5 days/week for 8 weeks, intraperitoneally). Our results indicated that treatment with curcumin in aged rats attenuates brain lipid peroxidation, which was accompanied by a significant increase in the BDNF, VEGF, superoxide dismutase (SOD) activity, and anti-apoptotic protein BCl-2. No significant change in brain anti-apoptotic Bax protein levels was observed after curcumin treatment. The study indicates that curcumin could alleviate brain aging which may be due to attenuating oxidative stress, inhibiting apoptosis, and up-regulating SOD activity, which in turn enhances VEGF and BDNF. Therefore, curcumin has potential therapeutic value in the treatment of neurological apoptosis, neurogenesis, and angiogenesis changes caused by brain aging.

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姜黄素通过减少细胞凋亡和氧化应激来延缓大脑衰老

大脑衰老是一种生理现象，氧化应激和细胞凋亡参与了大脑的自然衰老过程。姜黄素是一种天然抗氧化剂，具有很强的抗衰老和神经保护作用。因此，我们研究了姜黄素对老年大鼠脑凋亡和氧化应激、脑源性神经营养因子（BDNF）和血管内皮生长因子（VEGF）的保护作用。将老龄雌性 Wistar 大鼠随机分为以下三组（n = 7）：(1)对照组；(2)生理盐水组；(3)姜黄素组（腹腔注射姜黄素 30 毫克/千克，每周 5 天，连续 8 周）。我们的研究结果表明，姜黄素能减轻老年大鼠的脑脂质过氧化反应，同时BDNF、血管内皮生长因子、超氧化物歧化酶（SOD）活性和抗凋亡蛋白BCl-2也显著增加。姜黄素治疗后，脑部抗凋亡蛋白Bax水平未见明显变化。研究表明，姜黄素能缓解大脑衰老，这可能是由于姜黄素能减轻氧化应激、抑制细胞凋亡、上调 SOD 活性，进而增强血管内皮生长因子和 BDNF。因此，姜黄素在治疗脑衰老引起的神经系统凋亡、神经发生和血管生成变化方面具有潜在的治疗价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolic brain disease 医学-内分泌学与代谢

CiteScore

5.90

自引率

5.60%

发文量

248

审稿时长

6-12 weeks

期刊介绍： Metabolic Brain Disease serves as a forum for the publication of outstanding basic and clinical papers on all metabolic brain disease, including both human and animal studies. The journal publishes papers on the fundamental pathogenesis of these disorders and on related experimental and clinical techniques and methodologies. Metabolic Brain Disease is directed to physicians, neuroscientists, internists, psychiatrists, neurologists, pathologists, and others involved in the research and treatment of a broad range of metabolic brain disorders.