Microwave ablation combined with percutaneous vertebroplasty for treating painful non-small cell lung cancer with spinal metastases under real-time temperature monitoring

IF 1.4 4区 医学 Q4 ONCOLOGY
Linlin Wu, Miaomiao Hu, Peishun Li, Qirong Man, Qianqian Yuan, Xusheng Zhang, Yuanyuan Qiu, Lili Chen, Jing Fan, Kaixian Zhang
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引用次数: 0

Abstract

Purpose: 

To retrospectively study the therapeutic effect and safety performance of the combination strategies of the computed tomography (CT)-guided microwave ablation (MWA) and percutaneous vertebroplasty (PVP) as a treatment for painful non-small cell lung cancer (NSCLC) with spinal metastases.

Materials and Methods: 

A retrospective review included 71 patients with 109 vertebral metastases who underwent microwave ablation combined with percutaneous vertebroplasty by the image-guided and real-time temperature monitoring. Treatment efficacy was determined by comparing visual analog scale (VAS) scores, daily morphine equivalent opioid consumption, and Oswestry Disability Index (ODI) scores before treatment and during the follow-up period.

Results: 

Technical success was achieved in all patients. The mean pre-procedure VAS score and morphine doses were 6.6 ± 1.8 (4–10) and 137.2 ± 38.7 (40–200) mg, respectively. The mean VAS scores and daily morphine doses at 24 h and 1, 4, 12, and 24 weeks postoperatively were 3.3 ± 1.9 and 73.5 ± 39.4 mg; 2.2 ± 1.5 and 40.2 ± 29.8 mg; 1.7 ± 1.2 and 31.3 ± 23.6 mg; 1.4 ± 1.1 and 27.3 ± 21.4 mg; and 1.3 ± 1.1 and 24.8 ± 21.0 mg, respectively (all P < 0.001). ODI scores significantly decreased (P < 0.05). Minor cement leakage occurred in 51 cases (46.8%), with one patient having a grade 3 neural injury. No local tumor progression was observed by follow-up imaging.

Conclusions: 

MWA combined with PVP can significantly relieve pain and improve patients’ quality of life, which implied this is an effective treatment option for painful NSCLC with spinal metastases. Additionally, its efficacy should be further verified through the mid- and long-term studies.

微波消融结合经皮椎体成形术,在实时温度监测下治疗伴有脊柱转移的疼痛性非小细胞肺癌
目的:回顾性研究计算机断层扫描(CT)引导下的微波消融术(MWA)和经皮椎体成形术(PVP)联合治疗疼痛性非小细胞肺癌(NSCLC)脊柱转移的疗效和安全性:一项回顾性研究纳入了71例109椎体转移患者,他们在图像引导和实时温度监测下接受了微波消融联合经皮椎体成形术。通过比较治疗前和随访期间的视觉模拟量表(VAS)评分、每日吗啡当量阿片类药物消耗量和Oswestry残疾指数(ODI)评分来确定治疗效果:结果:所有患者都取得了技术成功。手术前的平均 VAS 评分和吗啡剂量分别为 6.6 ± 1.8(4-10)毫克和 137.2 ± 38.7(40-200)毫克。术后 24 小时、1、4、12 和 24 周的平均 VAS 评分和每日吗啡剂量分别为 3.3 ± 1.9 和 73.5 ± 39.4 毫克;2.2 ± 1.5 和 40.2 ± 29.8 毫克;1.7 ± 1.2 和 31.3 ± 23.6 毫克;1.4 ± 1.1 和 27.3 ± 21.4 毫克;以及 1.3 ± 1.1 和 24.8 ± 21.0 毫克(均为 P <0.001)。ODI 评分明显下降(P <0.05)。51例患者(46.8%)出现轻微骨水泥渗漏,其中一名患者出现3级神经损伤。随访影像学检查未发现局部肿瘤进展:结论:MWA联合PVP能明显缓解疼痛,改善患者的生活质量,这意味着这是一种治疗疼痛性NSCLC脊柱转移的有效方法。结论:MWA联合PVP能明显缓解疼痛,改善患者的生活质量,是治疗疼痛性NSCLC脊柱转移的有效方法,其疗效有待中长期研究进一步验证。
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来源期刊
CiteScore
1.80
自引率
15.40%
发文量
299
审稿时长
6 months
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of Medical oncology, radiation oncology, medical imaging, radiation protection, non-ionising radiation, radiobiology. Articles with clinical interest and implications will be given preference.
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