Diagnostic performances of Fibrosis-4 index and nonalcoholic fatty liver disease fibrosis score in metabolic dysfunction-associated steatotic liver disease in Asian primary care clinics

IF 3.9 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Hepatology Research Pub Date : 2024-05-04 DOI:10.1111/hepr.14054

Huiyul Park, Mimi Kim, Hye-Lin Kim, Seon Cho, Eileen L. Yoon, Dae Won Jun

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Abstract

Aims

We aimed to explore the extent to which individuals previously diagnosed with nonalcoholic fatty liver disease (NAFLD) meet the criteria fulfilled with the new nomenclature, metabolic dysfunction-associated steatotic liver disease (MASLD), within an Asian primary clinic cohort. Additionally, we assessed the reliability of the diagnostic performance of FIB-4 and NAFLD fibrosis score (NFS) for MASLD within the primary clinic cohort.

Methods

This retrospective cross-sectional study included participants who underwent magnetic resonance elastography and abdominal ultrasonography during their health checkups at nationwide health promotion centers (n = 6740).

Results

The prevalence rates of NAFLD and MASLD diagnosed based on ultrasonography results were 36.7% and 38.0%, respectively. Notably, 96.8% of patients in the NAFLD cohort fulfilled the new criteria for MASLD. A small proportion of patients with NAFLD (n = 80, 3.2%) did not meet the MASLD criteria. Additionally, 168 patients (6.6%) were newly added to the MASLD group. The areas under the receiver operating characteristic curves for diagnosing advanced hepatic fibrosis for FIB-4 (0.824 in NAFLD vs. 0.818 in MASLD, p = 0.891) and NFS (0.803 in NAFLD vs. 0.781 in MASLD, p = 0.618) were comparable between the MASLD and NAFLD groups. Furthermore, the sensitivity, specificity, positive predictive value, and negative predictive value of FIB-4 and NFS for advanced fibrosis in MASLD were also comparable to those in NAFLD.

Conclusions

Most patients (96.8%) previously diagnosed with NAFLD fulfilled the new criteria for MASLD in an Asian primary clinic cohort. Diagnostic performance of FIB-4 in the MASLD cohort demonstrated satisfactory results.

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纤维化-4 指数和非酒精性脂肪肝纤维化评分在亚洲初级保健诊所代谢功能障碍相关脂肪性肝病中的诊断性能

目的我们的目的是在一个亚洲基层诊所队列中，探讨以前诊断为非酒精性脂肪肝（NAFLD）的患者在多大程度上符合新命名法--代谢功能障碍相关性脂肪肝（MASLD）的标准。此外，我们还评估了 FIB-4 和 NAFLD 纤维化评分（NFS）在基层诊所队列中诊断 MASLD 的可靠性。结果根据超声波检查结果诊断出的 NAFLD 和 MASLD 患病率分别为 36.7% 和 38.0%。值得注意的是，96.8%的非酒精性脂肪肝患者符合MASLD的新标准。一小部分非酒精性脂肪肝患者（n = 80，3.2%）不符合MASLD标准。此外，有168名患者（6.6%）新加入了MASLD组。MASLD组和NAFLD组的FIB-4（NAFLD为0.824，MASLD为0.818，P = 0.891）和NFS（NAFLD为0.803，MASLD为0.781，P = 0.618）诊断晚期肝纤维化的接收器操作特征曲线下面积相当。此外，FIB-4 和 NFS 对 MASLD 晚期纤维化的敏感性、特异性、阳性预测值和阴性预测值也与 NAFLD 相当。FIB-4在MASLD队列中的诊断效果令人满意。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hepatology Research 医学-胃肠肝病学

CiteScore

8.30

自引率

14.30%

发文量

124

审稿时长

1 months

期刊介绍： Hepatology Research (formerly International Hepatology Communications) is the official journal of the Japan Society of Hepatology, and publishes original articles, reviews and short comunications dealing with hepatology. Reviews or mini-reviews are especially welcomed from those areas within hepatology undergoing rapid changes. Short communications should contain concise definitive information.