Effect of Rotenone on the Neurodegeneration among Different Models

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug targets Pub Date : 2024-05-03 DOI:10.2174/0113894501281496231226070459

Iqra Subhan, Yasir Hasan Siddique

引用次数: 0

Abstract

: Rotenone is a naturally occurring plant product used as an insecticide, pesticide and piscicide. It is lipophilic in nature and can cross the blood-brain barrier and induce the degeneration of neurons. It inhibits the mitochondrial respiratory chain complex I and stops the transfer of electrons. It induces ROS generation, which impairs mitochondrial activity. Rotenone is a toxic agent which causes the death of neurons. The present review describes the effect of rotenone on neurodegeneration with an emphasis on behavioral, pathological and neuropathological components carried out on various experimental models such as cell lines, Drosophila melanogaster, mice and rats.

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鱼藤酮对不同模型神经变性的影响

:腐霉利是一种天然植物产品，可用作杀虫剂、杀虫剂和杀鱼剂。它具有亲脂性，可以穿过血脑屏障，诱导神经元变性。它能抑制线粒体呼吸链复合物 I 并阻止电子的传递。它会诱导产生 ROS，从而损害线粒体的活性。轮酮是一种导致神经元死亡的有毒物质。本综述介绍了鱼藤酮对神经变性的影响，重点是在细胞系、黑腹果蝇、小鼠和大鼠等各种实验模型上进行的行为、病理和神经病理学研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug targets 医学-药学

CiteScore

6.20

自引率

0.00%

发文量

127

审稿时长

3-8 weeks

期刊介绍： Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies. As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.