Role of Insulin Use and Social Determinants of Health on Non-melanoma Skin Cancer: Results From the Behavioral Risk Factor Surveillance System

IF 2.5 4区 医学 Q3 ONCOLOGY
Nour Massouh, Ayad A. Jaffa, Miran A. Jaffa
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引用次数: 0

Abstract

BackgroundNon-melanoma skin cancer (NMSC) is a frequent type of malignancy with a steadily increasing incidence rate worldwide. Although NMSC was shown to be associated with diabetes, no studies have addressed the extent to which insulin use influences the risk of NMSC in light of social determinants of health (SDOH). We conducted a quantitative study that examined the interplay between insulin use, SDOH, additional covariates, and NMSC among individuals with diabetes.MethodsWe based our analysis on the 2020 Behavioral Risk Factor Surveillance System (BRFSS), a national survey conducted yearly in the US. We performed weighted chi-squared test, logistic regression, and survival analyses on 8685 eligible participants with diabetes enrolled in the BRFSS.ResultsKaplan Meier survival curves showed higher probability of NMSC event-free survival for participants with diabetes using insulin compared to participants with diabetes not using insulin (log-rank test P < .001). Significant associations were detected between insulin use and reduced odds of NMSC (OR .56; 95% CI: .38-.82), and decreased hazard (HR .36; 95% CI: .21-.62), along with indices of SDOH.ConclusionsOur findings suggest that socioeconomic differences related to the healthcare system and behavioral patterns are linked to discrepancies in the use of insulin and the development of NMSC.
胰岛素使用和健康的社会决定因素对非黑色素瘤皮肤癌的影响:行为风险因素监测系统的结果
背景非黑色素瘤皮肤癌(NMSC)是一种常见的恶性肿瘤,其发病率在全球范围内稳步上升。虽然非黑色素瘤皮肤癌与糖尿病有关,但目前还没有研究根据健康的社会决定因素(SDOH)来探讨使用胰岛素对非黑色素瘤皮肤癌风险的影响程度。我们进行了一项定量研究,探讨了糖尿病患者中胰岛素使用、SDOH、其他协变量和NMSC之间的相互作用。方法我们的分析基于2020年行为风险因素监测系统(BRFSS),这是一项每年在美国进行的全国性调查。结果卡普兰-麦尔生存曲线显示,与未使用胰岛素的糖尿病患者相比,使用胰岛素的糖尿病患者的无NMSC事件生存概率更高(对数秩检验P< .001)。胰岛素的使用与 NMSC 发生几率的降低(OR .56;95% CI:.38-.82)、危害的降低(HR .36;95% CI:.21-.62)以及 SDOH 指数之间存在显著关联。
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来源期刊
Cancer Control
Cancer Control ONCOLOGY-
CiteScore
3.80
自引率
0.00%
发文量
148
审稿时长
>12 weeks
期刊介绍: Cancer Control is a JCR-ranked, peer-reviewed open access journal whose mission is to advance the prevention, detection, diagnosis, treatment, and palliative care of cancer by enabling researchers, doctors, policymakers, and other healthcare professionals to freely share research along the cancer control continuum. Our vision is a world where gold-standard cancer care is the norm, not the exception.
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