Exploring potential correlations between HLA class II and the risk of microvascular complications in Japanese patients with type 1 diabetes

IF 2.9 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Journal of diabetes and its complications Pub Date : 2024-04-30 DOI:10.1016/j.jdiacomp.2024.108763

Eijiro Yamada, Risa Kajita, Haruna Takahashi, Kazuhiko Horiguchi, Satoshi Yoshino, Shunichi Matsumoto, Shuichi Okada, Masanobu Yamada

引用次数: 0

Abstract

Managing complications in Type 1 diabetes (T1D) remains challenging. HLA genes, particularly DR and DQ, are linked to T1D susceptibility. We studied 48 Japanese T1D inpatients and revealed associations between DRB1*04:05-DQB1*04:01 and DRB1*09:01-DQB1*03:03 haplotypes and complications, offering a new perspective for future research.

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探讨日本 1 型糖尿病患者 HLA Ⅱ级与微血管并发症风险之间的潜在相关性

控制 1 型糖尿病（T1D）并发症仍然是一项挑战。HLA 基因，尤其是 DR 和 DQ，与 T1D 易感性有关。我们对 48 名日本 T1D 住院患者进行了研究，发现 DRB1*04:05-DQB1*04:01 和 DRB1*09:01-DQB1*03:03 单倍型与并发症之间存在关联，为今后的研究提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of diabetes and its complications 医学-内分泌学与代谢

CiteScore

5.90

自引率

3.30%

发文量

153

审稿时长

16 days

期刊介绍： Journal of Diabetes and Its Complications (JDC) is a journal for health care practitioners and researchers, that publishes original research about the pathogenesis, diagnosis and management of diabetes mellitus and its complications. JDC also publishes articles on physiological and molecular aspects of glucose homeostasis. The primary purpose of JDC is to act as a source of information usable by diabetes practitioners and researchers to increase their knowledge about mechanisms of diabetes and complications development, and promote better management of people with diabetes who are at risk for those complications. Manuscripts submitted to JDC can report any aspect of basic, translational or clinical research as well as epidemiology. Topics can range broadly from early prediabetes to late-stage complicated diabetes. Topics relevant to basic/translational reports include pancreatic islet dysfunction and insulin resistance, altered adipose tissue function in diabetes, altered neuronal control of glucose homeostasis and mechanisms of drug action. Topics relevant to diabetic complications include diabetic retinopathy, neuropathy and nephropathy; peripheral vascular disease and coronary heart disease; gastrointestinal disorders, renal failure and impotence; and hypertension and hyperlipidemia.