Portland cement associated with niobium is evidenced by the presence of calcium crystals and biocompatibility in the rat subcutaneous tissue

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Journal of Materials Research Pub Date : 2024-04-29 DOI:10.1557/s43578-024-01349-x

Rafaela Alcindo Silva, Raphael Victor Silva Andrade, Agnes Andrade Martins, Valkleidson Santos de Araujo, Arnóbio Antônio da Silva Júnior, Ednaldo Gomes do Nascimento, Alcides de Oliveira Wanderley Neto, Gabriela de Souza Balbinot, Fabricio Mezzomo Collares, Ana Paula Negreiros Nunes Alves, Renata Ferreira de Carvalho Leitão, Conceição S. Martins Rebouças, Fábio Roberto Dametto, Rafael Rodrigues Lima, Salete Martins Alves, Aurigena Antunes de Araújo

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Abstract

This study evaluated the chemical, mechanical, and biocompatibility of Portland cement (PC) with different proportions of niobium oxide (Nb₂O₅). Five male Wistar rats were used. Four polyethylene tubes were placed on the dorsal subcutaneous tissue: one tube empty (NC), one tube MTA (Angelus®), one tube contained F6 (PC, Nb₂O₅ and CaSO₄), and one tube F7 (PC, Bi₂O₃, Nb₂O₅ and CaSO₄). After 60 days, animals were euthanized, and tubes were removed with the surrounding tissues. Inflammatory infiltrates were stained with hematoxylin–eosin. Mineralization was analyzed using Von Kossa staining and polarized light. The F6 showed small vessels and dispersed mononuclear inflammatory cells, score of 1 (1–2), p˃0.05 vs. NC 0.5 (0–1), and the absence of cell giants. Positive Von Kossa staining and birefringent structures under polarized light were observed with MTA, F6, and F7. The niobium oxide (Nb₂O₅), in association with Portland cement, exhibits calcium crystals and biocompatibility in rat subcutaneous tissue.

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与铌有关的硅酸盐水泥在大鼠皮下组织中的钙结晶和生物相容性证明了这一点

本研究评估了含有不同比例氧化铌（Nb2O5）的硅酸盐水泥（PC）的化学、机械和生物相容性。研究使用了五只雄性 Wistar 大鼠。在背侧皮下组织上放置了四根聚乙烯管：一根空管（NC）、一根 MTA 管（Angelus®）、一根含有 F6（PC、Nb2O5 和 CaSO4）的管子和一根 F7（PC、Bi2O3、Nb2O5 和 CaSO4）的管子。60 天后，动物被安乐死，管子和周围组织一起被移除。用苏木精-伊红对炎性浸润进行染色。使用 Von Kossa 染色法和偏振光分析矿化情况。F6 显示小血管和分散的单核炎症细胞，评分为 1（1-2），p˃0.05 与 NC 0.5（0-1）相比，没有细胞巨头。用 MTA、F6 和 F7 观察到阳性 Von Kossa 染色和偏振光下的双折射结构。氧化铌（Nb2O5）与波特兰水泥结合，在大鼠皮下组织中显示出钙结晶和生物相容性。

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来源期刊

Journal of Materials Research 工程技术-材料科学：综合

CiteScore

4.50

自引率

3.70%

发文量

362

审稿时长

2.8 months

期刊介绍： Journal of Materials Research (JMR) publishes the latest advances about the creation of new materials and materials with novel functionalities, fundamental understanding of processes that control the response of materials, and development of materials with significant performance improvements relative to state of the art materials. JMR welcomes papers that highlight novel processing techniques, the application and development of new analytical tools, and interpretation of fundamental materials science to achieve enhanced materials properties and uses. Materials research papers in the following topical areas are welcome. • Novel materials discovery • Electronic, photonic and magnetic materials • Energy Conversion and storage materials • New thermal and structural materials • Soft materials • Biomaterials and related topics • Nanoscale science and technology • Advances in materials characterization methods and techniques • Computational materials science, modeling and theory