Photodynamic impact of curcumin enhanced silver functionalized graphene nanocomposites on Candida virulence

IF 4.703 3区 材料科学
Dhivyabharathi Balakrishnan, Cheng-I Lee
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Abstract

Candida species are escalating resistance to conventional antifungal treatments, intensifying their virulence, and obstructing the effectiveness of antifungal medications. Addressing this challenge is essential for effectively managing Candida infections. The overarching objective is to advance the development of more efficient and precise therapies tailored to counter Candida infections. This study focuses on developing antifungal combined drugs using curcumin-enhanced silver-functionalized graphene nanocomposites (Cur-AgrGO) to effectively target key virulence factors of C. albicans, C. tropicalis, and C. glabrata (Candida spp.). The green reduction of graphene oxide (GO) using bioentities and active molecules makes this approach cost-effective and environmentally friendly. The nanocomposites were characterized using various techniques. Combining Cur-AgrGO with photodynamic therapy (PDT) demonstrated effective antifungal and antibiofilm activity with delayed growth and metabolism. The nanocomposites effectively suppressed hyphal transition and reduced key virulence factors, including proteinases, phospholipases, ergosterol levels, and cell membrane integrity. The findings suggest that Cur-AgrGO + PDT has potential as a treatment option for Candida infections. This innovative approach holds promise for treating Candida infections.

Graphical abstract

Abstract Image

姜黄素增强银功能化石墨烯纳米复合材料对念珠菌毒力的光动力影响
念珠菌对传统抗真菌治疗的耐药性不断增强,毒力不断加强,阻碍了抗真菌药物的疗效。应对这一挑战对于有效控制念珠菌感染至关重要。首要目标是推动开发更高效、更精确的治疗方法,以应对念珠菌感染。本研究的重点是利用姜黄素增强银功能化石墨烯纳米复合材料(Cur-AgrGO)开发抗真菌复合药物,以有效针对白色念珠菌、热带念珠菌和光滑念珠菌(念珠菌属)的关键毒力因子。利用生物实体和活性分子对氧化石墨烯(GO)进行绿色还原,使这种方法既经济又环保。利用各种技术对纳米复合材料进行了表征。Cur-AgrGO 与光动力疗法(PDT)的结合显示出有效的抗真菌和抗生物膜活性,并能延缓生长和新陈代谢。纳米复合材料有效抑制了菌丝的转化,减少了关键毒力因子,包括蛋白酶、磷脂酶、麦角固醇水平和细胞膜完整性。研究结果表明,Cur-AgrGO + PDT 具有治疗念珠菌感染的潜力。这种创新方法有望治疗念珠菌感染。
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来源期刊
Nanoscale Research Letters
Nanoscale Research Letters NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
15.00
自引率
0.00%
发文量
110
审稿时长
2.5 months
期刊介绍: Nanoscale Research Letters (NRL) provides an interdisciplinary forum for communication of scientific and technological advances in the creation and use of objects at the nanometer scale. NRL is the first nanotechnology journal from a major publisher to be published with Open Access.
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