Usefulness of Palliative Prognostic Index, Objective Prognostic Score, and Neutrophil–Lymphocyte Ratio/Albumin Ratio As Prognostic Indicators for Patients Without Cancer Receiving Home-Visit Palliative Care: A Pilot Study at a Community General Hospital

Taiki Hori, Ken-ichi Aihara, Koki Ishida, Kaori Inaba, Keisuke Inaba, Yousuke Kaneko, Keisuke Kawahito, Shoki Bekku, Minae Hosoki, Kensuke Mori, Kanako Itami, Masayo Katsuse, Yoshimi Hanaoka, Teruyoshi Kageji, Hideyuki Uraoka, S. Nakamura
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Abstract

Background: Although the palliative prognostic index (PPI), objective prognostic score (OPS), and neutrophil–lymphocyte ratio/albumin ratio (NLR/Alb) are well-known prognostic indicators for cancer patients, they do not provide clarity when it comes to predicting prognosis in patients without cancer who receive home-visit palliative care. Objective: The aim of this study was to determine whether PPI, OPS, and NLR/Alb can predict prognosis for patients without cancer who received home-visit palliative care. Design: This is a retrospective study. Setting/Subjects: We recruited 58 patients without cancer who received home-visit palliative care from Tokushima Prefectural Kaifu Hospital, Japan, and died at home or at the hospital within seven days of admission between January 2009 and March 2023. Measurements: The PPI, OPS, and NLR/Alb of the study patients were evaluated at regular intervals, and statistical analysis was performed on the relationship between these indices and the time to death. Results: Simple regression analysis showed that PPI, OPS, and NLR/Alb were negatively correlated with the period until death (p < 0.001). The survival curves of the groups classified according to PPI, OPS, and NLR/Alb were significantly stratified. The predictive capacities of PPI, OPS, and NLR/Alb for death within 21 days were as follows: PPI (area under the curve [AUC]: 0.71; sensitivity: 59%; specificity: 68%), OPS (AUC: 0.73; sensitivity: 88%; specificity: 47%), and NLR/Alb (AUC: 0.72; sensitivity: 72%; specificity: 73%). Conclusions: PPI, OPS, and NLR/Alb were useful in predicting the survival period and short-term prognosis within 21 days for patients without cancer who received home-visit palliative care.
姑息预后指数、客观预后评分和中性粒细胞-淋巴细胞比率/白蛋白比率作为接受居家探访姑息治疗的非癌症患者预后指标的实用性:一家社区综合医院的试点研究
背景:尽管姑息预后指数(PPI)、客观预后评分(OPS)和中性粒细胞-淋巴细胞比值/白蛋白比值(NLR/Alb)是众所周知的癌症患者预后指标,但它们在预测接受家庭访问姑息治疗的非癌症患者的预后方面并不明确。研究目的本研究旨在确定 PPI、OPS 和 NLR/Alb 是否能预测接受上门姑息治疗的非癌症患者的预后。研究设计这是一项回顾性研究。设置/受试者:我们从日本德岛县立开府医院招募了 58 名接受了上门姑息治疗的非癌症患者,这些患者在 2009 年 1 月至 2023 年 3 月期间入院七天内死于家中或医院。测量:定期评估研究对象的PPI、OPS和NLR/Alb,并对这些指数与死亡时间之间的关系进行统计分析。结果简单回归分析显示,PPI、OPS和NLR/Alb与死亡时间呈负相关(P < 0.001)。根据 PPI、OPS 和 NLR/Alb 分类的各组生存曲线明显分层。PPI、OPS和NLR/Alb对21天内死亡的预测能力如下:PPI(曲线下面积[AUC]:0.71;灵敏度:59%;特异度:68%)、OPS(AUC:0.73;灵敏度:88%;特异度:47%)和 NLR/Alb(AUC:0.72;灵敏度:72%;特异度:73%)。结论PPI、OPS和NLR/Alb有助于预测接受家访姑息治疗的非癌症患者21天内的生存期和短期预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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