A 3-year-old child with multifocal (thoracoabdominal) primary neuroblastoma: A case report and literature review

Pediatric Hematology Oncology Journal Pub Date : 2024-04-13 DOI:10.1016/j.phoj.2024.04.004

Ayesha Rahmat , Swaminathan Keerthivasagam , Sajid Qureshi , Puja Bathala , Mukta Ramadwar , Gramani Arumugam Vasugi , Harshavardhan Mahalingam , Vasundhara Patil , Dhaarani Jayaraman , Julius Xavier Scott

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引用次数: 0

Abstract

Introduction

Multifocal primary neuroblastoma in the non-infantile age group is rare, posing challenges in risk stratification and surgery.

Case report

A 3-year-old girl presented with an abdominal mass and elevated urinary vanillylmandelic acid (218 mg/l). Positron emission tomography - computed tomography showed fluorodeoxyglucose-avid masses in the left suprarenal and posterior mediastinum with regional paraortic nodes. A biopsy of the suprarenal and thoracic masses was suggestive of ganglioneuroblastoma and ganglioneuroma. She was stratified as an intermediate risk, with the bone marrow being uninvolved and non-amplified MYCN. Gross tumor resection was achieved at all the sites after 2 cycles of neoadjuvant chemotherapy. She received 2 more cycles of adjuvant chemotherapy and has been disease-free for 3 years.

Conclusion

Multifocal primaries in the non-infantile age group have favorable biological features and a good outcome.

查看原文本刊更多论文

一名患有多灶性原发性（胸腹）神经母细胞瘤的 3 岁儿童--病例报告和文献综述

病例报告一名 3 岁女童因腹部肿块和尿中香草酸（218 毫克/升）升高而就诊。正电子发射断层扫描-计算机断层扫描显示，左侧肾上和后纵隔有氟脱氧葡萄糖钙化肿块，并伴有区域性主动脉旁结节。肾上腺上部和胸部肿块的活组织检查提示为神经节神经母细胞瘤和神经节细胞瘤。她被列为中危患者，骨髓未受累，MYCN未扩增。经过两个周期的新辅助化疗后，所有部位的肿瘤均被切除。结论：非婴幼儿年龄组的多灶性原发性肿瘤具有良好的生物学特征和预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Hematology Oncology Journal

CiteScore

1.00

自引率

0.00%

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