Analysis of drug-related problems in ischemic stroke in-patients in one Indonesian district hospital

IF 0.5 Q4 EDUCATION, SCIENTIFIC DISCIPLINES

Pharmacy Education Pub Date : 2024-04-01 DOI:10.46542/pe.2024.242.134139

R. Andrajati, L. A. Kusumawardani, Isti Nurul Afifah, H. W. Risni

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引用次数: 0

Abstract

Background: Ischemic stroke is one of the leading causes of death in Indonesia. Appropriate management, including the identification of drug-related problems (DRPs), is needed to prevent disability and death. Objective: This study aimed to analyse DRPs as defined by the Pharmaceutical Care Network Europe (PCNE). Method: This was a cross-sectional research using the medical records of in-patients with ischemic stroke aged >18 years. Result: Out of the 115 patients examined, 51.3% were male, and the mean age was 57.85 + 10.539 years. Exactly 204 cases of DRPs and 175 causes appeared in 101 patients. A total of 58 patients experienced one-to-two problems, and 43 patients experienced more than two problems. The problems domain consists of therapeutic effectiveness (P1, 133(65.2%)), adverse effects (P2, 67(32, 84%)), and medical expenses (P3, 4(1, 96%)). The DRPs mostly involved antihypertension and antiplatelet. The most common cause was a new indication for treatment (C1.9, 51(29.14%)) and drug interactions (C8.1, 48(27.43%)). Multivariate analysis of patient characteristics showed that patients taking more than eight medications were more likely to experience more than two DRPs than those on one-to-four medications (OR 5.593; 95%, CI 1.015-30.812). Conclusion: Most patients experienced one-to-two DRPs with the highest being a potentially suboptimal treatment. Clinical pharmacists are expected to monitor therapy, especially in polypharmacy patients.

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印度尼西亚一家地区医院缺血性中风住院病人的药物相关问题分析

背景：缺血性中风是印度尼西亚的主要死亡原因之一。需要进行适当的管理，包括识别与药物相关的问题（DRPs），以预防残疾和死亡。研究目的本研究旨在分析欧洲药品护理网络（PCNE）定义的 DRP。研究方法这是一项横断面研究，使用的是年龄大于 18 岁的缺血性中风住院患者的医疗记录。研究结果在接受检查的 115 名患者中，51.3% 为男性，平均年龄为 57.85 + 10.539 岁。101名患者中出现了204例DRP和175个病因。共有 58 名患者出现一至两个问题，43 名患者出现两个以上问题。问题领域包括治疗效果（P1，133（65.2%））、不良反应（P2，67（32，84%））和医疗费用（P3，4（1，96%））。DRP 大多涉及抗高血压和抗血小板。最常见的原因是新的治疗适应症（C1.9，51（29.14%））和药物相互作用（C8.1，48（27.43%））。对患者特征的多变量分析表明，与服用一至四种药物的患者相比，服用八种以上药物的患者更有可能出现两次以上的 DRP（OR 5.593；95%，CI 1.015-30.812）。结论大多数患者的 DRP 为一至两次，最高的一次可能是次优治疗。临床药剂师应该对治疗进行监控，尤其是对使用多种药物的患者。

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来源期刊

Pharmacy Education EDUCATION, SCIENTIFIC DISCIPLINES-

CiteScore

0.80

自引率

20.00%

发文量

174

期刊介绍： Pharmacy Education journal provides a research, development and evaluation forum for communication between academic teachers, researchers and practitioners in professional and pharmacy education, with an emphasis on new and established teaching and learning methods, new curriculum and syllabus directions, educational outcomes, guidance on structuring courses and assessing achievement, and workforce development. It is a peer-reviewed online open access platform for the dissemination of new ideas in professional pharmacy education and workforce development. Pharmacy Education supports Open Access (OA): free, unrestricted online access to research outputs. Readers are able to access the Journal and individual published articles for free - there are no subscription fees or ''pay per view'' charges. Authors wishing to publish their work in Pharmacy Education do so without incurring any financial costs.