A patient with a Germline (p.R776H) EGFR Mutation With Multiple Lung Cancers Harboring Different Somatic EGFR Mutations

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-07-01 DOI:10.1016/j.cllc.2024.04.007

Iacopo Petrini , Rossella Bruno , Iosè Di Stefano , Vittorio Aprile , Stylianos Korasidis , Eleonora Pardini , Antonio Chella , Greta Alì

引用次数: 0

Abstract

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There are not standard guidelines for the selection and treatment of patients with synchronous multiple nodules with ground glass/lepidic features.
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The presence of different EGFR mutations in the various resected nodules with ground glass/lepidic features suggests the existence of multifocal primary tumors.
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The results suggest the possibility that a germline mutation in an oncogene could facilitate the development of a tumor with additional mutations in the same oncogene.