Hsf1 and Hsf2 in normal, healthy human tissues: Immunohistochemistry provokes new questions

IF 3.3 3区生物学 Q3 CELL BIOLOGY

Cell Stress & Chaperones Pub Date : 2024-04-18 DOI:10.1016/j.cstres.2024.04.004

Matthias P. Mayer

引用次数: 0

Abstract

The heat shock transcription factors heat shock transcription factor 1 and Hsf2 have been studied for many years, mainly in the context of stress response and in malignant cells. Their physiological function in nonmalignant human cells under nonstress conditions is still largely unknown. To approach this important issue, Joutsen et al. present immunohistochemical staining data on Hsf1 and Hsf2 in 80 nonpathological human tissue samples. The wealth of these data elicits many interesting questions that will spur many future research projects.

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正常健康人体组织中的 Hsf1 和 Hsf2：免疫组织化学提出了新问题。

热休克转录因子热休克转录因子 1 和 Hsf2 已被研究多年，主要是在应激反应和恶性细胞中。在非应激条件下，它们在非恶性人类细胞中的生理功能在很大程度上仍然未知。为了解决这一重要问题，Joutsen 等人展示了 80 个非病理人体组织样本中 Hsf1 和 Hsf2 的免疫组化染色数据。这些丰富的数据引出了许多有趣的问题，将刺激许多未来的研究项目。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Stress & Chaperones 生物-细胞生物学

CiteScore

7.60

自引率

2.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Cell Stress and Chaperones is an integrative journal that bridges the gap between laboratory model systems and natural populations. The journal captures the eclectic spirit of the cellular stress response field in a single, concentrated source of current information. Major emphasis is placed on the effects of climate change on individual species in the natural environment and their capacity to adapt. This emphasis expands our focus on stress biology and medicine by linking climate change effects to research on cellular stress responses of animals, micro-organisms and plants.