Additive Effects of Monetary Loss and Positive Emotion in the Human Brain

Abstract

In many real-life scenarios, our decisions could lead to multiple outcomes that conflict with value. Hence, an appropriate neural representation of the net experienced value of conflicting outcomes, which play a crucial role in guiding future decisions, is critical for adaptive behavior. As some recent functional neuroimaging work has primarily focused on the concurrent processing of monetary gains and aversive information, very little is known regarding the integration of conflicting value signals involving monetary losses and appetitive information in the human brain. To address this critical gap, we conducted a functional MRI study involving healthy human male participants to examine the nature of integrating positive emotion and monetary losses. We employed a novel experimental design where the valence (positive or neutral) of an emotional stimulus indicated the type of outcome (loss or no loss) in a choice task. Specifically, we probed two plausible integration patterns while processing conflicting value signals involving positive emotion and monetary losses: interactive versus additive. We found overlapping main effects of positive (vs neutral) emotion and loss (vs no loss) in multiple brain regions, including the ventromedial prefrontal cortex, striatum, and amygdala, notably with a lack of evidence for interaction. Thus, our findings revealed the additive integration pattern of monetary loss and positive emotion outcomes, suggesting that the experienced value of the monetary loss was not modulated by the valence of the image signaling those outcomes. These findings contribute to our limited understanding of the nature of integrating conflicting outcomes in the healthy human brain with potential clinical relevance.