Immunomodulatory and anti-inflammatory effects of bioactive compounds of Cassia angustifolia Vahl. leaf extract

Plant Science Today Pub Date : 2024-04-01 DOI:10.14719/pst.3159

Walaa Najm Abood

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Abstract

Cassia angustifolia Vahl. is a medicinal plant known for its efficacy in treating various, including respiratory conditions and skin inflammation. It possesses antibacterial and anticancer properties. This work investigated the immunomodulatory and anti-inflammatory effects of C. angustifolia. The ethanol leaf extract of C. angustifolia was utilized to examine gene expression related to angiogenesis cytokines in RAW 264.7 macrophage cells. The results demonstrated a significant increase in the viability of treated macrophage RAW 264.7 cells, accompanied by an improvement in angiogenesis cytokines expression and a dose-dependent inhibition of nitric oxide production. GC-MS analysis identified 11 active components within the extract, each exhibiting distinct biological activities such as antioxidant, antitumor and anti-inflammatory effects. Notable compounds include hexadecanoic acid, 2-pentadecanone, phthalic acid, oxalic acid, carbonic acid, tricosane, undecanal and many others. In conclusion, ethanol leaf extract of C. angustifolia exhibits immunomodulatory and anti-inflammatory effects by inhibiting nitric oxide production and enhancing the expression of angiogenesis cytokines.

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决明子叶提取物中生物活性化合物的免疫调节和抗炎作用

决明子（Cassia angustifolia Vahl.）是一种药用植物，以治疗各种疾病（包括呼吸道疾病和皮肤炎症）而闻名。它具有抗菌和抗癌特性。这项研究调查了藁本叶的免疫调节和抗炎作用。研究人员利用 C. angustifolia 的乙醇叶提取物检测 RAW 264.7 巨噬细胞中与血管生成细胞因子相关的基因表达。结果表明，经处理的 RAW 264.7 巨噬细胞的存活率明显提高，同时血管生成细胞因子的表达也有所改善，一氧化氮的产生也受到剂量依赖性抑制。GC-MS 分析确定了提取物中的 11 种活性成分，每种成分都具有不同的生物活性，如抗氧化、抗肿瘤和抗炎作用。值得注意的化合物包括十六酸、2-十五烷酮、邻苯二甲酸、草酸、碳酸、三聚氰酸、十一醛等。总之，C. angustifolia 的乙醇叶提取物通过抑制一氧化氮的产生和增强血管生成细胞因子的表达，具有免疫调节和抗炎作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Plant Science Today

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