FGF2 promotes the proliferation of injured granulosa cells in premature ovarian failure via Hippo-YAP signaling pathway

IF 3.8 3区医学 Q2 CELL BIOLOGY

Molecular and Cellular Endocrinology Pub Date : 2024-04-24 DOI:10.1016/j.mce.2024.112248

Feiyan Cheng , Jingyuan Wang , Rongli Wang , Rumeng Pan , Zhiwei Cui , Lijun Wang , Lihui Wang , Xinyuan Yang

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引用次数: 0

Abstract

Young women undergoing anticancer treatment are at risk of premature ovarian failure (POF). Endometrial-derived stem cells (EnSCs) have demonstrated significant therapeutic potential for treating ovarian insufficiency, although the underlying mechanisms remain to be fully understood. This study aims to further investigate the therapeutic effects of EnSCs, particularly through the paracrine action of fibroblast growth factor 2 (FGF2), on POF. The findings show that exogenous FGF2 enhances the survival of ovarian granulosa cells damaged by cisplatin. FGF2 stimulates the proliferation of these damaged cells by suppressing the Hippo signaling pathway and activating YAP expression. In vivo experiments also revealed that FGF2 treatment significantly improves ovarian reserve and endocrine function in mice with POF. These results suggest that FGF2 can boost the proliferative capacity of damaged ovarian granulosa cells through the Hippo-YAP signaling pathway, providing a theoretical foundation for using EnSCs and FGF2 in clinical treatments for POF.

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FGF2 通过 Hippo-YAP 信号通路促进卵巢早衰中受伤颗粒细胞的增殖

接受抗癌治疗的年轻女性面临卵巢早衰（POF）的风险。子宫内膜干细胞（EnSCs）在治疗卵巢功能不全方面具有显著的治疗潜力，但其潜在机制仍有待充分了解。本研究旨在进一步探讨EnSCs的治疗效果，特别是通过成纤维细胞生长因子2（FGF2）的旁分泌作用对卵巢功能不全的治疗效果。研究结果表明，外源性FGF2可提高受顺铂损伤的卵巢颗粒细胞的存活率。FGF2通过抑制Hippo信号通路和激活YAP的表达，刺激这些受损细胞的增殖。体内实验还发现，FGF2 治疗可显著改善 POF 小鼠的卵巢储备和内分泌功能。这些结果表明，FGF2可通过Hippo-YAP信号通路促进受损卵巢颗粒细胞的增殖能力，为将EnSCs和FGF2用于POF的临床治疗提供了理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular and Cellular Endocrinology 医学-内分泌学与代谢

CiteScore

9.00

自引率

2.40%

发文量

174

审稿时长

42 days

期刊介绍： Molecular and Cellular Endocrinology was established in 1974 to meet the demand for integrated publication on all aspects related to the genetic and biochemical effects, synthesis and secretions of extracellular signals (hormones, neurotransmitters, etc.) and to the understanding of cellular regulatory mechanisms involved in hormonal control.