Effect of tranexamic acid on postoperative blood loss

IF 1.7 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

British Journal of Oral & Maxillofacial Surgery Pub Date : 2024-06-01 DOI:10.1016/j.bjoms.2024.04.002

Benxing Wu , Kun Lv

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Abstract

The aim of this article was to evaluate the efficacy of tranexamic acid (TXA) to reduce blood loss after maxillofacial fracture surgery. Clinical data were collected retrospectively on patients with unilateral fractures of the zygomaticomaxillary complex (ZMC) or mandibular condyle. Patients were then further divided into TXA and control groups according to whether or not TXA was used after surgery. The amount of postoperative blood loss was evaluated by negative pressure drainage volume. Data were statistically analysed. In patients with unilateral ZMC fractures, total postoperative blood loss in the TXA group was about 30 ml less than that in the control group (p = 0.006). It was significantly less on the first and second postoperative days. However, in patients with unilateral mandibular condylar fractures, there was no significant difference between the TXA and control groups (p = 0.917). TXA can reduce postoperative bleeding in patients with ZMC fractures, and the optimal usage time is on the first and second postoperative days. For patients with mandibular condylar fractures, TXA may not be used.

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氨甲环酸对术后失血的影响

本文旨在评估氨甲环酸（TXA）在减少颌面部骨折术后失血量方面的疗效。本文回顾性地收集了单侧颧颌复合体（ZMC）或下颌骨髁状突骨折患者的临床数据。然后根据术后是否使用 TXA 将患者进一步分为 TXA 组和对照组。术后失血量通过负压引流量进行评估。对数据进行统计分析。在单侧 ZMC 骨折患者中，TXA 组的术后总失血量比对照组少约 30 毫升（P = 0.006）。术后第一天和第二天的失血量明显较少。然而，在单侧下颌骨髁突骨折患者中，TXA 组和对照组之间没有明显差异（p = 0.917）。TXA可以减少ZMC骨折患者的术后出血，最佳使用时间是术后第一天和第二天。对于下颌骨髁状突骨折患者，可以不使用 TXA。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British Journal of Oral & Maxillofacial Surgery 医学-外科

CiteScore

3.60

自引率

16.70%

发文量

256

审稿时长

6 months

期刊介绍： Journal of the British Association of Oral and Maxillofacial Surgeons: • Leading articles on all aspects of surgery in the oro-facial and head and neck region • One of the largest circulations of any international journal in this field • Dedicated to enhancing surgical expertise.