Feasibility and safety of contrast-enhanced magnetic resonance-guided adaptive radiotherapy for upper abdominal tumors: A preliminary exploration

IF 3.4 Q2 ONCOLOGY

Physics and Imaging in Radiation Oncology Pub Date : 2024-04-01 DOI:10.1016/j.phro.2024.100582

Wenheng Jiang , Xihua Shi , Xiang Zhang , Zhenjiang Li , Jinbo Yue

引用次数: 0

Abstract

This study investigates the use of contrast-enhanced magnetic resonance (MR) in MR-guided adaptive radiotherapy (MRgART) for upper abdominal tumors. Contrast-enhanced T1-weighted MR (cT1w MR) using half doses of gadoterate was used to guide daily adaptive radiotherapy for tumors poorly visualized without contrast. The use of gadoterate was found to be feasible and safe in 5-fraction MRgART and could improve the contrast-to-noise ratio of MR images. And the use of cT1w MR could reduce the interobserver variation of adaptive tumor delineation compared to plain T1w MR (4.41 vs. 6.58, p < 0.001) and T2w MR (4.41 vs. 7.42, p < 0.001).

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对比增强磁共振引导的上腹部肿瘤适应性放疗的可行性和安全性：初步探索

本研究探讨了造影剂增强磁共振（MR）在磁共振引导的上腹部肿瘤自适应放疗（MRgART）中的应用。使用半剂量的钆喷酸来进行对比增强 T1 加权磁共振（cT1w MR），以指导日常自适应放疗，用于治疗无对比剂情况下可视性差的肿瘤。研究发现，在 5 分 MRgART 中使用钆喷酸是可行和安全的，并能提高 MR 图像的对比度-噪声比。与普通 T1w MR（4.41 vs. 6.58，p < 0.001）和 T2w MR（4.41 vs. 7.42，p < 0.001）相比，使用 cT1w MR 可减少自适应肿瘤分界的观察者间差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physics and Imaging in Radiation Oncology Physics and Astronomy-Radiation

CiteScore

5.30

自引率

18.90%

发文量

审稿时长

6 weeks