A Rare Cause of Coagulopathy in the Emergency Department: Cefoperazone Use

IF 1.8 4区医学 Q2 EMERGENCY MEDICINE

Journal of Emergency Nursing Pub Date : 2024-07-01 DOI:10.1016/j.jen.2024.03.003

Metin Ocak MD, Hatice Yıldız MD, Metin Yadigaroğlu MD, Murat Yücel MD, Murat Güzel MD

引用次数: 0

Abstract

Cefoperazone (CPZ) is an antibiotic widely used for moderate to severe infections, especially in countries where resources are difficult to access. This case report aimed to draw attention to coagulopathy, a potential side effect of CPZ. This side effect can cause high mortality and morbidity in patients. In the mechanism of CPZ causing coagulopathy, it is reported that effects such as binding to vitamin K, disrupting vitamin K metabolism, and preventing platelet aggregation are responsible. In this presentation, a case who came to the emergency department with the complaint of hematuria caused by coagulopathy after the use of CPZ-containing antibiotics (CPZ + sulbactam) is presented.

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急诊科凝血病的罕见病因：使用头孢哌酮

头孢哌酮（CPZ）是一种广泛用于治疗中度至重度感染的抗生素，尤其是在资源难以获得的国家。本病例报告旨在引起人们对 CPZ 潜在副作用--凝血病的关注。这种副作用可导致患者的高死亡率和高发病率。据报道，CPZ 引起凝血病的机制是与维生素 K 结合、干扰维生素 K 代谢和阻止血小板聚集等作用。本文介绍了一例因使用含 CPZ 的抗生素（CPZ + 舒巴坦）后发生凝血病导致血尿而到急诊科就诊的病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Emergency Nursing 医学-护理

CiteScore

3.10

自引率

11.80%

发文量

132

审稿时长

46 days

期刊介绍： The Journal of Emergency Nursing, the official journal of the Emergency Nurses Association (ENA), is committed to the dissemination of high quality, peer-reviewed manuscripts relevant to all areas of emergency nursing practice across the lifespan. Journal content includes clinical topics, integrative or systematic literature reviews, research, and practice improvement initiatives that provide emergency nurses globally with implications for translation of new knowledge into practice. The Journal also includes focused sections such as case studies, pharmacology/toxicology, injury prevention, trauma, triage, quality and safety, pediatrics and geriatrics. The Journal aims to mirror the goal of ENA to promote: community, governance and leadership, knowledge, quality and safety, and advocacy.